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- W2059091190 abstract "Activated V gamma 9 V delta 2 T cells are able to kill most tumour cells because of recognition by T cell receptor and natural killer receptors.We discuss the possibility that the intentional activation of gammadelta T cells in vivo by aminobisphosphonates may represent a promising target for the design of novel and highly innovative immunotherapy in cancer patients.The antitumoral effects of gammadelta T cells both in vitro and in vivo have been demonstrated suggesting a new therapeutic approach for translation into the clinical setting.V gamma 9 V delta 2 T lymphocytes represent a particularly interesting target for immunotherapeutic protocols based on N-aminobisphosphonate administration and several Phase I-II trials are ongoing investigating the activity of zoledronic acid plus IL-2 in solid tumours." @default.
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- W2059091190 date "2008-06-12" @default.
- W2059091190 modified "2023-10-03" @default.
- W2059091190 title "Aminobisphosphonate-activated γδ T cells in immunotherapy of cancer: doubts no more" @default.
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- W2059091190 doi "https://doi.org/10.1517/14712598.8.7.875" @default.
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