Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059091210> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2059091210 endingPage "145" @default.
- W2059091210 startingPage "135" @default.
- W2059091210 abstract "The effect of intravenous furosemide, 5 mg/kg, on renal hemodynamics as it relates to the prostaglandin cascade was examined in dogs. In 11 dogs the vasculature to the kidney was isolated and a femoral to renal arterial and a renal to femoral venous shunt was performed. With the use of a protein-free salt solution to perfuse the kidney for 3 minutes, the renal cortex was enriched with tritiated arachidonic acid. After blood perfusion to the kidney was re-established, the renal effluent radioactivity was followed before and after furosemide administration. Furosemide produced two types of response. In six dogs there was renal vasodilation, diuresis, and a three and one-half fold increase in renal venous radioactivity. In five dogs that were in renal failure, furosemide administration caused no change in renal blood flow, no diuresis and no increase in renal venous effluent radioactivity. On thin-layer chromatography most of the released radioactivity by the kidney after furosemide administration traveled as arachidonic acid. In a separate seven dogs, we measured the total unesterified arachidonic acid concentration in the plasma before and after furosemide by the use of gas chromatographyflame ionization. Even though in these dogs furosemide caused a significant increase in renal blood flow and diuresis, renal venous plasma levels of arachidonic acid were unaltered. Our data suggest that furosemide causes a release of arachidonic acid from the kidney from a small pool of fast turnover lipid stores and that the stimulus for arachidonic acid release after furosemide depends on an intrarenal mechanism whereby the diuresis is coupled to the increase in renal blood flow." @default.
- W2059091210 created "2016-06-24" @default.
- W2059091210 creator A5056820048 @default.
- W2059091210 creator A5077616203 @default.
- W2059091210 date "1981-02-01" @default.
- W2059091210 modified "2023-10-15" @default.
- W2059091210 title "Interaction between furosemide-induced renal vasodilation and the prostaglandin system" @default.
- W2059091210 cites W1972609990 @default.
- W2059091210 cites W1980377638 @default.
- W2059091210 cites W2018206720 @default.
- W2059091210 cites W2068299980 @default.
- W2059091210 cites W2094170850 @default.
- W2059091210 cites W2285289861 @default.
- W2059091210 cites W2304110330 @default.
- W2059091210 cites W2406194611 @default.
- W2059091210 cites W4233038992 @default.
- W2059091210 cites W101545525 @default.
- W2059091210 doi "https://doi.org/10.1016/0161-4630(81)90084-7" @default.
- W2059091210 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7244026" @default.
- W2059091210 hasPublicationYear "1981" @default.
- W2059091210 type Work @default.
- W2059091210 sameAs 2059091210 @default.
- W2059091210 citedByCount "16" @default.
- W2059091210 crossrefType "journal-article" @default.
- W2059091210 hasAuthorship W2059091210A5056820048 @default.
- W2059091210 hasAuthorship W2059091210A5077616203 @default.
- W2059091210 hasConcept C126322002 @default.
- W2059091210 hasConcept C134018914 @default.
- W2059091210 hasConcept C142225936 @default.
- W2059091210 hasConcept C181199279 @default.
- W2059091210 hasConcept C185592680 @default.
- W2059091210 hasConcept C2777955127 @default.
- W2059091210 hasConcept C2778078955 @default.
- W2059091210 hasConcept C2778577996 @default.
- W2059091210 hasConcept C2779547328 @default.
- W2059091210 hasConcept C2780091579 @default.
- W2059091210 hasConcept C55493867 @default.
- W2059091210 hasConcept C71924100 @default.
- W2059091210 hasConceptScore W2059091210C126322002 @default.
- W2059091210 hasConceptScore W2059091210C134018914 @default.
- W2059091210 hasConceptScore W2059091210C142225936 @default.
- W2059091210 hasConceptScore W2059091210C181199279 @default.
- W2059091210 hasConceptScore W2059091210C185592680 @default.
- W2059091210 hasConceptScore W2059091210C2777955127 @default.
- W2059091210 hasConceptScore W2059091210C2778078955 @default.
- W2059091210 hasConceptScore W2059091210C2778577996 @default.
- W2059091210 hasConceptScore W2059091210C2779547328 @default.
- W2059091210 hasConceptScore W2059091210C2780091579 @default.
- W2059091210 hasConceptScore W2059091210C55493867 @default.
- W2059091210 hasConceptScore W2059091210C71924100 @default.
- W2059091210 hasIssue "2" @default.
- W2059091210 hasLocation W20590912101 @default.
- W2059091210 hasLocation W20590912102 @default.
- W2059091210 hasOpenAccess W2059091210 @default.
- W2059091210 hasPrimaryLocation W20590912101 @default.
- W2059091210 hasRelatedWork W1502367766 @default.
- W2059091210 hasRelatedWork W1973548116 @default.
- W2059091210 hasRelatedWork W2015188843 @default.
- W2059091210 hasRelatedWork W2023645914 @default.
- W2059091210 hasRelatedWork W2034845783 @default.
- W2059091210 hasRelatedWork W2042060688 @default.
- W2059091210 hasRelatedWork W2043350902 @default.
- W2059091210 hasRelatedWork W2255232369 @default.
- W2059091210 hasRelatedWork W2403246566 @default.
- W2059091210 hasRelatedWork W4212953671 @default.
- W2059091210 hasVolume "6" @default.
- W2059091210 isParatext "false" @default.
- W2059091210 isRetracted "false" @default.
- W2059091210 magId "2059091210" @default.
- W2059091210 workType "article" @default.