Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059092455> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2059092455 abstract "T lymphocytes undergo a complex series of developmental events in the thymus to become mature but naive circulating T cells. These naive T cells are activated during the response to pathogens to produce immune mediators and undergo further differentiation to give rise to distinct types of effector or memory cells. Each of these differentiation and activation events leads to major changes in gene expression patterns. The chromatin structure across a gene is one of the underlying mechanisms that determine its expression level in a specific cell type or in response to an activating signal. The changes in chromatin structure that occur across specific gene loci during differentiation and activation of T cells have been studied in detail in recent years and in many cases, they provide paradigms for the role of chromatin in differentiation and activation in other cell systems. Epigenetic marking and chromatin structure can be viewed as reversible or irreversible states and both appear to play major roles in controlling gene expression patterns in T cells. Reversibility is important for the quick response of cells to their environment, while irreversibility serves to lock in the specific patterns of gene expression that define distinct cell lineages. Changes in the modification state of histone proteins, the strength of histone: DNA contact, the methylation status of the DNA and nuclear location, all serve to determine chromatin structure and accessibility. Here we review the role of chromatin remodelling and epigenetic marking in regulating patterns of T cell gene expression. © 2006 Bentham Science Publishers Ltd." @default.
- W2059092455 created "2016-06-24" @default.
- W2059092455 creator A5013234730 @default.
- W2059092455 creator A5028262165 @default.
- W2059092455 creator A5028462736 @default.
- W2059092455 creator A5088119801 @default.
- W2059092455 date "2006-08-01" @default.
- W2059092455 modified "2023-09-23" @default.
- W2059092455 title "Chromatin Remodelling: Distinct Molecular Events During Differentiation and Activation of T Cells" @default.
- W2059092455 doi "https://doi.org/10.2174/157339506778018587" @default.
- W2059092455 hasPublicationYear "2006" @default.
- W2059092455 type Work @default.
- W2059092455 sameAs 2059092455 @default.
- W2059092455 citedByCount "1" @default.
- W2059092455 countsByYear W20590924552012 @default.
- W2059092455 crossrefType "journal-article" @default.
- W2059092455 hasAuthorship W2059092455A5013234730 @default.
- W2059092455 hasAuthorship W2059092455A5028262165 @default.
- W2059092455 hasAuthorship W2059092455A5028462736 @default.
- W2059092455 hasAuthorship W2059092455A5088119801 @default.
- W2059092455 hasConcept C104317684 @default.
- W2059092455 hasConcept C137338518 @default.
- W2059092455 hasConcept C148738053 @default.
- W2059092455 hasConcept C150194340 @default.
- W2059092455 hasConcept C165864922 @default.
- W2059092455 hasConcept C167227067 @default.
- W2059092455 hasConcept C190727270 @default.
- W2059092455 hasConcept C41091548 @default.
- W2059092455 hasConcept C51785407 @default.
- W2059092455 hasConcept C54355233 @default.
- W2059092455 hasConcept C64927066 @default.
- W2059092455 hasConcept C83640560 @default.
- W2059092455 hasConcept C86803240 @default.
- W2059092455 hasConcept C95444343 @default.
- W2059092455 hasConceptScore W2059092455C104317684 @default.
- W2059092455 hasConceptScore W2059092455C137338518 @default.
- W2059092455 hasConceptScore W2059092455C148738053 @default.
- W2059092455 hasConceptScore W2059092455C150194340 @default.
- W2059092455 hasConceptScore W2059092455C165864922 @default.
- W2059092455 hasConceptScore W2059092455C167227067 @default.
- W2059092455 hasConceptScore W2059092455C190727270 @default.
- W2059092455 hasConceptScore W2059092455C41091548 @default.
- W2059092455 hasConceptScore W2059092455C51785407 @default.
- W2059092455 hasConceptScore W2059092455C54355233 @default.
- W2059092455 hasConceptScore W2059092455C64927066 @default.
- W2059092455 hasConceptScore W2059092455C83640560 @default.
- W2059092455 hasConceptScore W2059092455C86803240 @default.
- W2059092455 hasConceptScore W2059092455C95444343 @default.
- W2059092455 hasLocation W20590924551 @default.
- W2059092455 hasOpenAccess W2059092455 @default.
- W2059092455 hasPrimaryLocation W20590924551 @default.
- W2059092455 hasRelatedWork W1979245454 @default.
- W2059092455 hasRelatedWork W2006138959 @default.
- W2059092455 hasRelatedWork W2090037368 @default.
- W2059092455 hasRelatedWork W2522469407 @default.
- W2059092455 hasRelatedWork W2784229030 @default.
- W2059092455 hasRelatedWork W3007472244 @default.
- W2059092455 hasRelatedWork W3016501695 @default.
- W2059092455 hasRelatedWork W3135719074 @default.
- W2059092455 hasRelatedWork W4226146636 @default.
- W2059092455 hasRelatedWork W607960219 @default.
- W2059092455 isParatext "false" @default.
- W2059092455 isRetracted "false" @default.
- W2059092455 magId "2059092455" @default.
- W2059092455 workType "article" @default.