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• W2059093496 abstract "Serum levels of calcium, phosphorus, alkaline phosphatase, 250HD, 1,25(0H)2D and PTH were studied in a group of 42 children aged 8.5 ± 1.8 years (X ± SD) from the city of Ushuaia (latitude 55°S), at both the end of the winter and the end of summer. Calcium, phosphorus, alkaline phosphatase and 1,25(OH)2D serum levels were not different in summer and winter. The levels of serum 250HD were significantly higher in summer (18.4 ± 7.3 ng/ml) than in winter (9.8 ± 3.8 ng/ml (P < 0.001). The levels of 250HD in children with fair or dark skin were similar in winter but were significantly higher in children with fair skin in summer (20.0 ± 7.2 ng/l vs 15.3 ± 5.1 ng/ml (P < 0.05). Serum levels of PTH were higher in winter (58.2 ± 30.5 pg/ml) than in summer (47.9 ± 28.3 pg/ml) (P < 0.03). The results demonstrate the existence of a population with low serum levels of 250HD in winter. The higher levels of PTH in winter when serum 250HD levels are lower could be the cause of the lack of seasonal variation in serum calcium and 1,25(OH)2D levels. Further studies are needed to establish whether these changes besides increasing the incidence of rickets, could also affect the mineral density of the skeleton in the population of this vitamin-D-deficient area." @default.
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• W2059093496 date "1993-01-01" @default.
• W2059093496 modified "2023-09-27" @default.
• W2059093496 title "Seasonal variations of 25 hydroxyvitamin D and parathyroid hormone in Ushuaia (Argentina), the southernmost city of the world" @default.
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• W2059093496 doi "https://doi.org/10.1016/s0169-6009(08)80041-4" @default.
• W2059093496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8453326" @default.
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