Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059093520> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2059093520 endingPage "C42" @default.
- W2059093520 startingPage "C35" @default.
- W2059093520 abstract "Although European guidelines indicate that treatment for chronic heart failure (CHF) should be started with an angiotensin-converting enzyme (ACE) inhibitor, followed by a beta-blocker, this order is not evidence-based. The order of initiation may be important because patients often cannot tolerate optimum doses of both an ACE-inhibitor and a beta-blocker. The first-prescribed agent is likely to be titrated to a higher dose, and the second agent may not be prescribed at all. There are arguments for starting a beta-blocker first, as the sympathetic nervous system is activated earlier in CHF than the renin–angiotensin–aldosterone system. Beta-blockers have a more pronounced effect on early left ventricular (LV) remodelling than ACE-inhibitors. Moreover, sudden cardiac death (the most prevalent mode of death in early and mild CHF) is markedly reduced by beta-blockers but not by ACE-inhibitors. The third Cardiac Insufficiency Bisoprolol Study was designed to determine whether a betablocker could be safely and effectively initiated first in CHF. It was a controlled openlabel non-inferiority trial, including 1010 patients aged � 65 years, in stable New York Heart Association class II or III, and with LV ejection fraction � 35%. Patients received 6 months of monotherapy with either bisoprolol (target dose 10 mg od, n ¼ 505) or enalapril (target dose 10 mg bid, n ¼ 505), followed by their combination for 6–24 months. The combined primary endpoint was all-cause mortality or hospitalization." @default.
- W2059093520 created "2016-06-24" @default.
- W2059093520 creator A5017272571 @default.
- W2059093520 date "2006-06-01" @default.
- W2059093520 modified "2023-09-25" @default.
- W2059093520 title "Rationale and design of CIBIS III" @default.
- W2059093520 cites W1967340565 @default.
- W2059093520 cites W1967454817 @default.
- W2059093520 cites W1970448985 @default.
- W2059093520 cites W1980649708 @default.
- W2059093520 cites W1981850993 @default.
- W2059093520 cites W1987016701 @default.
- W2059093520 cites W1993104550 @default.
- W2059093520 cites W1994316999 @default.
- W2059093520 cites W2001880687 @default.
- W2059093520 cites W2007088839 @default.
- W2059093520 cites W2019605946 @default.
- W2059093520 cites W2020800966 @default.
- W2059093520 cites W2021144122 @default.
- W2059093520 cites W2023650178 @default.
- W2059093520 cites W2025970694 @default.
- W2059093520 cites W2029600692 @default.
- W2059093520 cites W2029626316 @default.
- W2059093520 cites W2030609170 @default.
- W2059093520 cites W2036770224 @default.
- W2059093520 cites W2046494590 @default.
- W2059093520 cites W2050625434 @default.
- W2059093520 cites W2059231427 @default.
- W2059093520 cites W2070568974 @default.
- W2059093520 cites W2070844603 @default.
- W2059093520 cites W2073603280 @default.
- W2059093520 cites W2082096141 @default.
- W2059093520 cites W2082351345 @default.
- W2059093520 cites W2084479364 @default.
- W2059093520 cites W2085596429 @default.
- W2059093520 cites W2095634382 @default.
- W2059093520 cites W2097653089 @default.
- W2059093520 cites W2110062302 @default.
- W2059093520 cites W2115203478 @default.
- W2059093520 cites W2116234771 @default.
- W2059093520 cites W2118714387 @default.
- W2059093520 cites W2122290203 @default.
- W2059093520 cites W2124037698 @default.
- W2059093520 cites W2137412139 @default.
- W2059093520 cites W2137534212 @default.
- W2059093520 cites W2139888542 @default.
- W2059093520 cites W21478844 @default.
- W2059093520 cites W2159396821 @default.
- W2059093520 cites W2165141146 @default.
- W2059093520 cites W2172146634 @default.
- W2059093520 cites W2296998040 @default.
- W2059093520 cites W2312388685 @default.
- W2059093520 cites W2326354230 @default.
- W2059093520 cites W2326508838 @default.
- W2059093520 cites W2338638760 @default.
- W2059093520 cites W2469805673 @default.
- W2059093520 cites W2494656477 @default.
- W2059093520 cites W2585382523 @default.
- W2059093520 cites W3023522280 @default.
- W2059093520 cites W4230893588 @default.
- W2059093520 cites W4245244523 @default.
- W2059093520 cites W52877415 @default.
- W2059093520 doi "https://doi.org/10.1093/eurheartj/sul012" @default.
- W2059093520 hasPublicationYear "2006" @default.
- W2059093520 type Work @default.
- W2059093520 sameAs 2059093520 @default.
- W2059093520 citedByCount "1" @default.
- W2059093520 crossrefType "journal-article" @default.
- W2059093520 hasAuthorship W2059093520A5017272571 @default.
- W2059093520 hasBestOaLocation W20590935201 @default.
- W2059093520 hasConcept C126322002 @default.
- W2059093520 hasConcept C71924100 @default.
- W2059093520 hasConceptScore W2059093520C126322002 @default.
- W2059093520 hasConceptScore W2059093520C71924100 @default.
- W2059093520 hasIssue "suppl_C" @default.
- W2059093520 hasLocation W20590935201 @default.
- W2059093520 hasOpenAccess W2059093520 @default.
- W2059093520 hasPrimaryLocation W20590935201 @default.
- W2059093520 hasRelatedWork W1506200166 @default.
- W2059093520 hasRelatedWork W1995515455 @default.
- W2059093520 hasRelatedWork W2039318446 @default.
- W2059093520 hasRelatedWork W2048182022 @default.
- W2059093520 hasRelatedWork W2080531066 @default.
- W2059093520 hasRelatedWork W2604872355 @default.
- W2059093520 hasRelatedWork W2748952813 @default.
- W2059093520 hasRelatedWork W2899084033 @default.
- W2059093520 hasRelatedWork W3032375762 @default.
- W2059093520 hasRelatedWork W3108674512 @default.
- W2059093520 hasVolume "8" @default.
- W2059093520 isParatext "false" @default.
- W2059093520 isRetracted "false" @default.
- W2059093520 magId "2059093520" @default.
- W2059093520 workType "article" @default.