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• W2059094579 abstract "Benzodiazepines increase vulnerability to infection through α1 subunit dependent Υ-amino-butyric-type-A (GABAA) signalling. Immune cell expression of GABAA receptors and the effect of diazepam on influenza infection was investigated. In patients with pneumonia, α1 GABAA subunits were expressed on alveolar macrophages and blood monocytes. In mice, influenza induced dynamic changes in immune cell GABAA subunit expression: α1 subunits decreased on alveolar macrophage, but increased on monocytes, CD4+ and CD8+ T cells. Following influenza viral infection, diazepam delayed weight loss on day 3 but later increased weight loss. Viral load was unaffected but increased bacterial superinfection was noted on day 10." @default.
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• W2059094579 date "2015-05-01" @default.
• W2059094579 modified "2023-09-23" @default.
• W2059094579 title "Immune cell expression of GABAA receptors and the effects of diazepam on influenza infection" @default.
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• W2059094579 doi "https://doi.org/10.1016/j.jneuroim.2015.04.001" @default.
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