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• W2059095246 abstract "The synthesis and biological evaluation of N-benzyl-(piperidin or pyrrolidin)-purines are described. Compounds derived from N-benzylpiperidine and N-substituted purines showed moderate acetylcholinesterase inhibition. Preliminary structure–activity relationships and a superimposition of the best compound with the active conformation of donepezil have revealed structural features that have been used in the design of more potent N-benzylpiperidine inhibitors bearing an 8-substituted caffeine fragment and a methoxymethyl linker. These new compounds are interesting dual inhibitors of acetylcholinesterase and butyrylcholinesterase and have been chosen for further optimisation." @default.
• W2059095246 created "2016-06-24" @default.
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• W2059095246 date "2005-12-01" @default.
• W2059095246 modified "2023-10-18" @default.
• W2059095246 title "Design and synthesis of N-benzylpiperidine–purine derivatives as new dual inhibitors of acetyl- and butyrylcholinesterase" @default.
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• W2059095246 doi "https://doi.org/10.1016/j.bmc.2005.07.019" @default.
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