FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059096370> ?p ?o ?g. }

• W2059096370 endingPage "2818" @default.
• W2059096370 startingPage "2806" @default.
• W2059096370 abstract "This study is an extension of a previously published microsome composition-based model by Poulin and Haddad (Poulin and Haddad. 2011. J Pharm Sci 100:4501–4517), which was converted to the hepatocyte composition-based model. The first objective was to investigate the ability of the composition-based model to predict nonspecific binding of drugs in hepatocytes suspended in the incubation medium in in vitro metabolic studies. The hepatocyte composition-based model describes the cell suspension-aqueous phase partition coefficients, which were used to estimate fraction unbound in the incubation medium (fuinc) for each drug. The second objective was to make a comparative analysis between the proposed hepatocyte composition-based model and an empirical regression equation published in the literature by Austin et al. (Austin RP, Barton P, Mohmed S, Riley RJ. 2004. Drug Metab Dispos 33:419–425). The assessment was confined by the availability of experimentally determined in vitro fuinc values at diverse hepatocyte concentrations for 92 drugs. The model that made use of hepatocyte composition data provides comparable or superior prediction performance compared with the regression equation that relied solely on physicochemical data; therefore, this demonstrates the ability of predicting fuinc also based on mechanisms of drug tissue distribution. The accuracy of the predictions differed depending on the class of drugs (neutrals vs. ionized drugs) and species (rat vs. human) for each method. This study for hepatocytes corroborates a previous study for microsomes. Overall, this work represents a significant first step toward the development of a generic and mechanistic calculation method of fuinc in incubations of hepatocytes, which should facilitate rational interindividual and interspecies extrapolations of fuinc by considering differences in lipid composition of hepatocytes, for clearance prediction in the physiologically-based pharmacokinetics (PBPK) models. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 102:2806–2818, 2013" @default.
• W2059096370 created "2016-06-24" @default.
• W2059096370 creator A5051609996 @default.
• W2059096370 creator A5070588264 @default.
• W2059096370 date "2013-08-01" @default.
• W2059096370 modified "2023-10-15" @default.
• W2059096370 title "Hepatocyte Composition-Based Model as a Mechanistic Tool for Predicting the Cell Suspension: Aqueous Phase Partition Coefficient of Drugs in In Vitro Metabolic Studies" @default.
• W2059096370 cites W1964935486 @default.
• W2059096370 cites W1965996612 @default.
• W2059096370 cites W1970977102 @default.
• W2059096370 cites W1972459982 @default.
• W2059096370 cites W1978655276 @default.
• W2059096370 cites W1980653441 @default.
• W2059096370 cites W1987574056 @default.
• W2059096370 cites W1987804903 @default.
• W2059096370 cites W1996949498 @default.
• W2059096370 cites W2000619652 @default.
• W2059096370 cites W2003441704 @default.
• W2059096370 cites W2005314435 @default.
• W2059096370 cites W2010780586 @default.
• W2059096370 cites W2020223089 @default.
• W2059096370 cites W2028151943 @default.
• W2059096370 cites W2028523934 @default.
• W2059096370 cites W2031652509 @default.
• W2059096370 cites W2036756894 @default.
• W2059096370 cites W2052939585 @default.
• W2059096370 cites W2061915365 @default.
• W2059096370 cites W2090947827 @default.
• W2059096370 cites W2093620978 @default.
• W2059096370 cites W2095319468 @default.
• W2059096370 cites W2095973346 @default.
• W2059096370 cites W2098130430 @default.
• W2059096370 cites W2098154721 @default.
• W2059096370 cites W2101168835 @default.
• W2059096370 cites W2102551031 @default.
• W2059096370 cites W2111070729 @default.
• W2059096370 cites W2131559621 @default.
• W2059096370 cites W2133677036 @default.
• W2059096370 cites W2150823598 @default.
• W2059096370 cites W2151605862 @default.
• W2059096370 cites W2153728590 @default.
• W2059096370 cites W2171101358 @default.
• W2059096370 cites W2329697035 @default.
• W2059096370 doi "https://doi.org/10.1002/jps.23602" @default.
• W2059096370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23670739" @default.
• W2059096370 hasPublicationYear "2013" @default.
• W2059096370 type Work @default.
• W2059096370 sameAs 2059096370 @default.
• W2059096370 citedByCount "20" @default.
• W2059096370 countsByYear W20590963702014 @default.
• W2059096370 countsByYear W20590963702015 @default.
• W2059096370 countsByYear W20590963702016 @default.
• W2059096370 countsByYear W20590963702017 @default.
• W2059096370 countsByYear W20590963702019 @default.
• W2059096370 countsByYear W20590963702020 @default.
• W2059096370 countsByYear W20590963702021 @default.
• W2059096370 countsByYear W20590963702022 @default.
• W2059096370 crossrefType "journal-article" @default.
• W2059096370 hasAuthorship W2059096370A5051609996 @default.
• W2059096370 hasAuthorship W2059096370A5070588264 @default.
• W2059096370 hasConcept C138885662 @default.
• W2059096370 hasConcept C185592680 @default.
• W2059096370 hasConcept C192552737 @default.
• W2059096370 hasConcept C202751555 @default.
• W2059096370 hasConcept C2776200302 @default.
• W2059096370 hasConcept C40231798 @default.
• W2059096370 hasConcept C41895202 @default.
• W2059096370 hasConcept C43617362 @default.
• W2059096370 hasConcept C55493867 @default.
• W2059096370 hasConcept C87644729 @default.
• W2059096370 hasConceptScore W2059096370C138885662 @default.
• W2059096370 hasConceptScore W2059096370C185592680 @default.
• W2059096370 hasConceptScore W2059096370C192552737 @default.
• W2059096370 hasConceptScore W2059096370C202751555 @default.
• W2059096370 hasConceptScore W2059096370C2776200302 @default.
• W2059096370 hasConceptScore W2059096370C40231798 @default.
• W2059096370 hasConceptScore W2059096370C41895202 @default.
• W2059096370 hasConceptScore W2059096370C43617362 @default.
• W2059096370 hasConceptScore W2059096370C55493867 @default.
• W2059096370 hasConceptScore W2059096370C87644729 @default.
• W2059096370 hasIssue "8" @default.
• W2059096370 hasLocation W20590963701 @default.
• W2059096370 hasLocation W20590963702 @default.
• W2059096370 hasOpenAccess W2059096370 @default.
• W2059096370 hasPrimaryLocation W20590963701 @default.
• W2059096370 hasRelatedWork W1502035638 @default.
• W2059096370 hasRelatedWork W1999669358 @default.
• W2059096370 hasRelatedWork W2058324269 @default.
• W2059096370 hasRelatedWork W2063917169 @default.
• W2059096370 hasRelatedWork W2087639700 @default.
• W2059096370 hasRelatedWork W2414084612 @default.
• W2059096370 hasRelatedWork W2914877943 @default.
• W2059096370 hasRelatedWork W2946316715 @default.
• W2059096370 hasRelatedWork W4224947583 @default.
• W2059096370 hasRelatedWork W4304689636 @default.
• W2059096370 hasVolume "102" @default.
• W2059096370 isParatext "false" @default.
• W2059096370 isRetracted "false" @default.

• next