Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059098144> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2059098144 endingPage "567" @default.
- W2059098144 startingPage "561" @default.
- W2059098144 abstract "Both p15and p16are tumor suppressor genes that have 5′ CpG islands; aberrant cytosine methylation of these islands has been associated with silencing of their expression. Deoxycytidine kinase (dCK) converts prodrugs to their cytotoxic form, has a 5′ CpG island and is a candidate gene for inactivation by hypermethylation. In our study, we used sodium bisulfite sequencing to generate high resolution maps of 5-methylcytosine in the CpG islands associated with p15, p16 and dCK in normal human bone marrow (BM), peripheral blood lymphocytes (PBL) and cytosine arabinoside (ara-C)-resistant acute myeloid leukemia (AML) patients, and established human hematopoietic tumor cell lines. In normal cells the p15, p16and dCK CpG islands were largely unmethylated. The p16 and dCK CpG islands were also unmethylated in the 8 AML specimens. In contrast, the p15CpG island was aberrantly methylated in 6 of the 8 AML specimens. Furthermore, bisulfite sequencing revealed that the p15CpG island is heterogeneously methylated in AML, with large intra-individual and inter-individual variability.Int. J. Cancer 78:561–567, 1998. © 1998 Wiley-Liss, Inc." @default.
- W2059098144 created "2016-06-24" @default.
- W2059098144 creator A5029797248 @default.
- W2059098144 creator A5053324798 @default.
- W2059098144 creator A5065716888 @default.
- W2059098144 date "1998-11-23" @default.
- W2059098144 modified "2023-10-11" @default.
- W2059098144 title "Selective variegated methylation of thep15 CpG island in acute myeloid leukemia" @default.
- W2059098144 cites W1869160040 @default.
- W2059098144 cites W1968263601 @default.
- W2059098144 cites W1969373767 @default.
- W2059098144 cites W1977706798 @default.
- W2059098144 cites W1995927666 @default.
- W2059098144 cites W1999510229 @default.
- W2059098144 cites W2001258296 @default.
- W2059098144 cites W2032426692 @default.
- W2059098144 cites W2046370286 @default.
- W2059098144 cites W2066848701 @default.
- W2059098144 cites W2070136352 @default.
- W2059098144 cites W2084748297 @default.
- W2059098144 doi "https://doi.org/10.1002/(sici)1097-0215(19981123)78:5<561::aid-ijc6>3.0.co;2-r" @default.
- W2059098144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9808523" @default.
- W2059098144 hasPublicationYear "1998" @default.
- W2059098144 type Work @default.
- W2059098144 sameAs 2059098144 @default.
- W2059098144 citedByCount "71" @default.
- W2059098144 countsByYear W20590981442012 @default.
- W2059098144 countsByYear W20590981442013 @default.
- W2059098144 countsByYear W20590981442014 @default.
- W2059098144 countsByYear W20590981442015 @default.
- W2059098144 countsByYear W20590981442016 @default.
- W2059098144 countsByYear W20590981442017 @default.
- W2059098144 countsByYear W20590981442020 @default.
- W2059098144 crossrefType "journal-article" @default.
- W2059098144 hasAuthorship W2059098144A5029797248 @default.
- W2059098144 hasAuthorship W2059098144A5053324798 @default.
- W2059098144 hasAuthorship W2059098144A5065716888 @default.
- W2059098144 hasBestOaLocation W20590981441 @default.
- W2059098144 hasConcept C104317684 @default.
- W2059098144 hasConcept C121608353 @default.
- W2059098144 hasConcept C140173407 @default.
- W2059098144 hasConcept C150194340 @default.
- W2059098144 hasConcept C153911025 @default.
- W2059098144 hasConcept C189235521 @default.
- W2059098144 hasConcept C190727270 @default.
- W2059098144 hasConcept C203014093 @default.
- W2059098144 hasConcept C2777844706 @default.
- W2059098144 hasConcept C2778461978 @default.
- W2059098144 hasConcept C2778729363 @default.
- W2059098144 hasConcept C2779268695 @default.
- W2059098144 hasConcept C2779282312 @default.
- W2059098144 hasConcept C2780007613 @default.
- W2059098144 hasConcept C2780258809 @default.
- W2059098144 hasConcept C33288867 @default.
- W2059098144 hasConcept C502942594 @default.
- W2059098144 hasConcept C54355233 @default.
- W2059098144 hasConcept C86803240 @default.
- W2059098144 hasConceptScore W2059098144C104317684 @default.
- W2059098144 hasConceptScore W2059098144C121608353 @default.
- W2059098144 hasConceptScore W2059098144C140173407 @default.
- W2059098144 hasConceptScore W2059098144C150194340 @default.
- W2059098144 hasConceptScore W2059098144C153911025 @default.
- W2059098144 hasConceptScore W2059098144C189235521 @default.
- W2059098144 hasConceptScore W2059098144C190727270 @default.
- W2059098144 hasConceptScore W2059098144C203014093 @default.
- W2059098144 hasConceptScore W2059098144C2777844706 @default.
- W2059098144 hasConceptScore W2059098144C2778461978 @default.
- W2059098144 hasConceptScore W2059098144C2778729363 @default.
- W2059098144 hasConceptScore W2059098144C2779268695 @default.
- W2059098144 hasConceptScore W2059098144C2779282312 @default.
- W2059098144 hasConceptScore W2059098144C2780007613 @default.
- W2059098144 hasConceptScore W2059098144C2780258809 @default.
- W2059098144 hasConceptScore W2059098144C33288867 @default.
- W2059098144 hasConceptScore W2059098144C502942594 @default.
- W2059098144 hasConceptScore W2059098144C54355233 @default.
- W2059098144 hasConceptScore W2059098144C86803240 @default.
- W2059098144 hasIssue "5" @default.
- W2059098144 hasLocation W20590981441 @default.
- W2059098144 hasLocation W20590981442 @default.
- W2059098144 hasOpenAccess W2059098144 @default.
- W2059098144 hasPrimaryLocation W20590981441 @default.
- W2059098144 hasRelatedWork W2033244804 @default.
- W2059098144 hasRelatedWork W2123238153 @default.
- W2059098144 hasRelatedWork W2169344098 @default.
- W2059098144 hasRelatedWork W2364944693 @default.
- W2059098144 hasRelatedWork W2380976670 @default.
- W2059098144 hasRelatedWork W2582088144 @default.
- W2059098144 hasRelatedWork W2944524138 @default.
- W2059098144 hasRelatedWork W3029570287 @default.
- W2059098144 hasRelatedWork W4200236841 @default.
- W2059098144 hasRelatedWork W4210559607 @default.
- W2059098144 hasVolume "78" @default.
- W2059098144 isParatext "false" @default.
- W2059098144 isRetracted "false" @default.
- W2059098144 magId "2059098144" @default.
- W2059098144 workType "article" @default.