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- W2059098230 abstract "We have employed an amino derivative of the imidazoline ligand, efaroxan, to isolate imidazoline binding proteins from solubilised extracts of rat brain, by affinity chromatography. A number of proteins were specifically retained on the affinity column and one of these was immunoreactive with an antiserum raised against the ion conducting pore component of the ATP-sensitive potassium channel. Patch clamp experiments confirmed that, like its parent compound, amino-efaroxan blocks ATP-sensitive potassium channels in human pancreatic beta-cells and can stimulate the insulin secretion from these cells. The results reveal that a member of the ion conducting pore component family is strongly associated with imidazoline binding proteins in brain and in the endocrine pancreas." @default.
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- W2059098230 date "1999-03-19" @default.
- W2059098230 modified "2023-09-27" @default.
- W2059098230 title "Affinity isolation of imidazoline binding proteins from rat brain using 5-amino-efaroxan as a ligand" @default.
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- W2059098230 doi "https://doi.org/10.1016/s0014-5793(99)00264-1" @default.
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