FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059118051> ?p ?o ?g. }

• W2059118051 endingPage "950" @default.
• W2059118051 startingPage "943" @default.
• W2059118051 abstract "The influence of anthracyclines on membrane permeability functions has been investigated in HeLa cells by monitoring the efflux of fluorescein. Release of the fluorescent dye, dependent on the metabolic energy supply, occurs after the intracellular accumulation and enzymatic hydrolysis of the non-fluorescent substrate fluorescein diacetate (FDA). Flow cytometric evaluation of the efflux kinetics showed that adriamycin (ADR), N-trifluoroacetyladriamycin-14-valerate (AD-32) and daunorubicin (DNR) inhibited the permeability process. The degree of inhibition was dependent, though to different extent, on the intracellular concentration of each drug. An increase in the efflux rate was always observed when the cells were treated with the drugs in the presence of 20 mM glucose. Relationship of these effects with energetic metabolism was supported by the finding that ATP levels were lowered by the drugs and increased by glucose. Evaluation of the cytotoxicity induced by each drug showed that the intracellular amount necessary to inhibit cell survival by 50% was of the same order of magnitude as that which decreases to 50% membrane permeability to fluorescein. These results indicate a correspondence in the concentrations of anthracyclines required for inducing cytotoxicity and for inhibiting membrane permeability functions dependent on the metabolic energy supply." @default.
• W2059118051 created "2016-06-24" @default.
• W2059118051 creator A5041620597 @default.
• W2059118051 creator A5047923861 @default.
• W2059118051 creator A5084662956 @default.
• W2059118051 creator A5087215059 @default.
• W2059118051 date "1986-12-01" @default.
• W2059118051 modified "2023-10-06" @default.
• W2059118051 title "Anthracycline-induced inhibition of membrane permeability functions dependent on metabolic energy" @default.
• W2059118051 cites W1520124386 @default.
• W2059118051 cites W1549176003 @default.
• W2059118051 cites W1551677938 @default.
• W2059118051 cites W1562692935 @default.
• W2059118051 cites W1775749144 @default.
• W2059118051 cites W1972380212 @default.
• W2059118051 cites W1974219191 @default.
• W2059118051 cites W1980181948 @default.
• W2059118051 cites W1991354483 @default.
• W2059118051 cites W1994913349 @default.
• W2059118051 cites W1995124186 @default.
• W2059118051 cites W2001537957 @default.
• W2059118051 cites W2014593961 @default.
• W2059118051 cites W2028524183 @default.
• W2059118051 cites W2033256212 @default.
• W2059118051 cites W2033728911 @default.
• W2059118051 cites W2034189690 @default.
• W2059118051 cites W2046155014 @default.
• W2059118051 cites W2069613887 @default.
• W2059118051 cites W2072794292 @default.
• W2059118051 cites W2083102892 @default.
• W2059118051 cites W2083625430 @default.
• W2059118051 cites W2084674228 @default.
• W2059118051 cites W2086253892 @default.
• W2059118051 cites W2090497028 @default.
• W2059118051 cites W2102310386 @default.
• W2059118051 cites W2140165759 @default.
• W2059118051 cites W2163807756 @default.
• W2059118051 cites W2419273626 @default.
• W2059118051 cites W2461451977 @default.
• W2059118051 cites W3089521080 @default.
• W2059118051 doi "https://doi.org/10.1038/bjc.1986.265" @default.
• W2059118051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2001592" @default.
• W2059118051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3801290" @default.
• W2059118051 hasPublicationYear "1986" @default.
• W2059118051 type Work @default.
• W2059118051 sameAs 2059118051 @default.
• W2059118051 citedByCount "4" @default.
• W2059118051 crossrefType "journal-article" @default.
• W2059118051 hasAuthorship W2059118051A5041620597 @default.
• W2059118051 hasAuthorship W2059118051A5047923861 @default.
• W2059118051 hasAuthorship W2059118051A5084662956 @default.
• W2059118051 hasAuthorship W2059118051A5087215059 @default.
• W2059118051 hasBestOaLocation W20591180512 @default.
• W2059118051 hasConcept C109316439 @default.
• W2059118051 hasConcept C120882062 @default.
• W2059118051 hasConcept C121332964 @default.
• W2059118051 hasConcept C12554922 @default.
• W2059118051 hasConcept C153911025 @default.
• W2059118051 hasConcept C185592680 @default.
• W2059118051 hasConcept C200082930 @default.
• W2059118051 hasConcept C202751555 @default.
• W2059118051 hasConcept C203014093 @default.
• W2059118051 hasConcept C2778015030 @default.
• W2059118051 hasConcept C2778461978 @default.
• W2059118051 hasConcept C2781021840 @default.
• W2059118051 hasConcept C2992270614 @default.
• W2059118051 hasConcept C41625074 @default.
• W2059118051 hasConcept C553184892 @default.
• W2059118051 hasConcept C55493867 @default.
• W2059118051 hasConcept C62520636 @default.
• W2059118051 hasConcept C79879829 @default.
• W2059118051 hasConcept C86803240 @default.
• W2059118051 hasConcept C91881484 @default.
• W2059118051 hasConcept C98274493 @default.
• W2059118051 hasConceptScore W2059118051C109316439 @default.
• W2059118051 hasConceptScore W2059118051C120882062 @default.
• W2059118051 hasConceptScore W2059118051C121332964 @default.
• W2059118051 hasConceptScore W2059118051C12554922 @default.
• W2059118051 hasConceptScore W2059118051C153911025 @default.
• W2059118051 hasConceptScore W2059118051C185592680 @default.
• W2059118051 hasConceptScore W2059118051C200082930 @default.
• W2059118051 hasConceptScore W2059118051C202751555 @default.
• W2059118051 hasConceptScore W2059118051C203014093 @default.
• W2059118051 hasConceptScore W2059118051C2778015030 @default.
• W2059118051 hasConceptScore W2059118051C2778461978 @default.
• W2059118051 hasConceptScore W2059118051C2781021840 @default.
• W2059118051 hasConceptScore W2059118051C2992270614 @default.
• W2059118051 hasConceptScore W2059118051C41625074 @default.
• W2059118051 hasConceptScore W2059118051C553184892 @default.
• W2059118051 hasConceptScore W2059118051C55493867 @default.
• W2059118051 hasConceptScore W2059118051C62520636 @default.
• W2059118051 hasConceptScore W2059118051C79879829 @default.
• W2059118051 hasConceptScore W2059118051C86803240 @default.
• W2059118051 hasConceptScore W2059118051C91881484 @default.
• W2059118051 hasConceptScore W2059118051C98274493 @default.
• W2059118051 hasIssue "6" @default.
• W2059118051 hasLocation W20591180511 @default.
• W2059118051 hasLocation W20591180512 @default.

• next