Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059122010> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2059122010 endingPage "1726" @default.
- W2059122010 startingPage "1722" @default.
- W2059122010 abstract "Hydrogen sulphide is a recently identified endogenous endothelium-dependent vasodilator. Animal models of diabetes have shown that low plasma H(2)S levels are associated with marked endothelial dysfunction and insulin resistance. However, human studies on H(2)S and vascular function in health and disease are lacking.Plasma was obtained from male patients with type 2 diabetes (n = 11), overweight (n = 16) and lean (n = 11) volunteers. H(2)S levels were determined by zinc trap spectrophotometry. Anthropometric measurements (BMI/waist:hip ratio), lipid profile, systemic blood pressure, biochemical indices of diabetes (fasting glucose, insulin sensitivity, Hb(1Ac)) and microvascular function (minimum vascular resistance) were determined.Median plasma H(2)S levels (25th, 75th percentiles) in age-matched lean, overweight and type 2 diabetes individuals were 38.9 (29.7, 45.1) micromol/l, 22.0 (18.6, 26.7) micromol/l and 10.5 (4.8, 22.0) micromol/l, respectively. Median plasma H(2)S levels were significantly lower in patients with type 2 diabetes compared with lean (p = 0.001, Mann-Whitney) and overweight participants (p = 0.008). Median plasma H(2)S levels in overweight participants were significantly lower than in lean controls (p = 0.003). Waist circumference was an independent predictor of plasma H(2)S (R (2) = 0.423, standardised beta: -0.650, p < 0.001). This relationship was independent of diabetes, which only contributed a further 5% to the model (R (2) = 0.477). Waist circumference or other measures of adiposity (waist:hip ratio/BMI) remained independent predictors of plasma H(2)S after adjustment for systolic blood pressure, microvascular function, insulin sensitivity, glycaemic control and lipid profile.Plasma H(2)S levels are reduced in overweight participants and patients with type 2 diabetes. Increasing adiposity is a major determinant of plasma H(2)S levels." @default.
- W2059122010 created "2016-06-24" @default.
- W2059122010 creator A5019853358 @default.
- W2059122010 creator A5029851798 @default.
- W2059122010 creator A5035840732 @default.
- W2059122010 creator A5069136351 @default.
- W2059122010 creator A5072883388 @default.
- W2059122010 creator A5075502305 @default.
- W2059122010 creator A5079230138 @default.
- W2059122010 creator A5084368234 @default.
- W2059122010 date "2010-04-23" @default.
- W2059122010 modified "2023-10-10" @default.
- W2059122010 title "Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide" @default.
- W2059122010 cites W1980967170 @default.
- W2059122010 cites W1999619247 @default.
- W2059122010 cites W2001860318 @default.
- W2059122010 cites W2023355100 @default.
- W2059122010 cites W2072682750 @default.
- W2059122010 cites W2100784798 @default.
- W2059122010 cites W2110742798 @default.
- W2059122010 cites W2113063186 @default.
- W2059122010 cites W2122478264 @default.
- W2059122010 doi "https://doi.org/10.1007/s00125-010-1761-5" @default.
- W2059122010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20414636" @default.
- W2059122010 hasPublicationYear "2010" @default.
- W2059122010 type Work @default.
- W2059122010 sameAs 2059122010 @default.
- W2059122010 citedByCount "202" @default.
- W2059122010 countsByYear W20591220102012 @default.
- W2059122010 countsByYear W20591220102013 @default.
- W2059122010 countsByYear W20591220102014 @default.
- W2059122010 countsByYear W20591220102015 @default.
- W2059122010 countsByYear W20591220102016 @default.
- W2059122010 countsByYear W20591220102017 @default.
- W2059122010 countsByYear W20591220102018 @default.
- W2059122010 countsByYear W20591220102019 @default.
- W2059122010 countsByYear W20591220102020 @default.
- W2059122010 countsByYear W20591220102021 @default.
- W2059122010 countsByYear W20591220102022 @default.
- W2059122010 countsByYear W20591220102023 @default.
- W2059122010 crossrefType "journal-article" @default.
- W2059122010 hasAuthorship W2059122010A5019853358 @default.
- W2059122010 hasAuthorship W2059122010A5029851798 @default.
- W2059122010 hasAuthorship W2059122010A5035840732 @default.
- W2059122010 hasAuthorship W2059122010A5069136351 @default.
- W2059122010 hasAuthorship W2059122010A5072883388 @default.
- W2059122010 hasAuthorship W2059122010A5075502305 @default.
- W2059122010 hasAuthorship W2059122010A5079230138 @default.
- W2059122010 hasAuthorship W2059122010A5084368234 @default.
- W2059122010 hasBestOaLocation W20591220101 @default.
- W2059122010 hasConcept C126322002 @default.
- W2059122010 hasConcept C134018914 @default.
- W2059122010 hasConcept C2776193436 @default.
- W2059122010 hasConcept C2777180221 @default.
- W2059122010 hasConcept C2777391703 @default.
- W2059122010 hasConcept C2780586474 @default.
- W2059122010 hasConcept C511355011 @default.
- W2059122010 hasConcept C555293320 @default.
- W2059122010 hasConcept C71924100 @default.
- W2059122010 hasConceptScore W2059122010C126322002 @default.
- W2059122010 hasConceptScore W2059122010C134018914 @default.
- W2059122010 hasConceptScore W2059122010C2776193436 @default.
- W2059122010 hasConceptScore W2059122010C2777180221 @default.
- W2059122010 hasConceptScore W2059122010C2777391703 @default.
- W2059122010 hasConceptScore W2059122010C2780586474 @default.
- W2059122010 hasConceptScore W2059122010C511355011 @default.
- W2059122010 hasConceptScore W2059122010C555293320 @default.
- W2059122010 hasConceptScore W2059122010C71924100 @default.
- W2059122010 hasIssue "8" @default.
- W2059122010 hasLocation W20591220101 @default.
- W2059122010 hasLocation W20591220102 @default.
- W2059122010 hasOpenAccess W2059122010 @default.
- W2059122010 hasPrimaryLocation W20591220101 @default.
- W2059122010 hasRelatedWork W1974154791 @default.
- W2059122010 hasRelatedWork W2119752015 @default.
- W2059122010 hasRelatedWork W2373621818 @default.
- W2059122010 hasRelatedWork W2389001773 @default.
- W2059122010 hasRelatedWork W2531582387 @default.
- W2059122010 hasRelatedWork W2759571287 @default.
- W2059122010 hasRelatedWork W2906156617 @default.
- W2059122010 hasRelatedWork W2978010786 @default.
- W2059122010 hasRelatedWork W3168052018 @default.
- W2059122010 hasRelatedWork W4313149604 @default.
- W2059122010 hasVolume "53" @default.
- W2059122010 isParatext "false" @default.
- W2059122010 isRetracted "false" @default.
- W2059122010 magId "2059122010" @default.
- W2059122010 workType "article" @default.