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• W2059122258 abstract "Recent technologies have allowed high-resolution genome-wide binding profiles of numerous transcription factors and other proteins. A widespread observation has emerged from studies in diverse mammalian systems: most binding events are located at great distances from gene promoters. It is becoming apparent that the traditional one-dimensional view of gene regulation via the proximal cis regulatory elements is over-simplified. True proximity and functional relevance can be revealed by studying the three-dimensional structure of the genome packaged inside the nucleus. Thus the spatial architecture of the genome has attracted a lot of interest and has intensified its significance in modern cell biology. Here we discuss current methods, concepts, and controversies in this rapidly evolving field." @default.
• W2059122258 created "2016-06-24" @default.
• W2059122258 creator A5023528108 @default.
• W2059122258 creator A5042213683 @default.
• W2059122258 creator A5060518160 @default.
• W2059122258 date "2010-06-01" @default.
• W2059122258 modified "2023-09-27" @default.
• W2059122258 title "3D shortcuts to gene regulation" @default.
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• W2059122258 doi "https://doi.org/10.1016/j.ceb.2010.04.005" @default.
• W2059122258 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2916936" @default.
• W2059122258 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20466532" @default.
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