Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059126872> ?p ?o ?g. }
- W2059126872 endingPage "423" @default.
- W2059126872 startingPage "413" @default.
- W2059126872 abstract "Modulation of a specific prostanoid synthase or receptor provides therapeutic alternatives to nonsteroidal anti-inflammatory drugs (NSAIDs) for treating pathological conditions governed by cyclooxygenase-2 (COX-2 or PTGS2). Among the COX-2 downstream signaling pathways, the prostaglandin E2 (PGE2) receptor EP2 subtype (PTGER2) is emerging as a crucial mediator of many physiological and pathological events. Genetic ablation strategies and recent advances in chemical biology provide tools for a better understanding of EP2 signaling. In the brain, the EP2 receptor modulates some beneficial effects, including neuroprotection, in acute models of excitotoxicity, neuroplasticity, and spatial learning via cAMP-PKA signaling. Conversely, EP2 activation accentuates chronic inflammation mainly through the cAMP-Epac pathway, likely contributing to delayed neurotoxicity. EP2 receptor activation also engages β-arrestin in a G-protein-independent pathway that promotes tumor cell growth and migration. Understanding the conditions under which multiple EP2 signaling pathways are engaged might suggest novel therapeutic strategies to target this key inflammatory prostaglandin receptor." @default.
- W2059126872 created "2016-06-24" @default.
- W2059126872 creator A5041248710 @default.
- W2059126872 creator A5063483736 @default.
- W2059126872 date "2013-07-01" @default.
- W2059126872 modified "2023-09-25" @default.
- W2059126872 title "Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection" @default.
- W2059126872 cites W1495790818 @default.
- W2059126872 cites W1514189093 @default.
- W2059126872 cites W1525044292 @default.
- W2059126872 cites W1526354182 @default.
- W2059126872 cites W1535056291 @default.
- W2059126872 cites W1551599120 @default.
- W2059126872 cites W1738485982 @default.
- W2059126872 cites W1940681873 @default.
- W2059126872 cites W1947838700 @default.
- W2059126872 cites W1963685103 @default.
- W2059126872 cites W1966052610 @default.
- W2059126872 cites W1968358948 @default.
- W2059126872 cites W1968524827 @default.
- W2059126872 cites W1968537403 @default.
- W2059126872 cites W1972809962 @default.
- W2059126872 cites W1974631216 @default.
- W2059126872 cites W1975743527 @default.
- W2059126872 cites W1977816613 @default.
- W2059126872 cites W1978804708 @default.
- W2059126872 cites W1980020952 @default.
- W2059126872 cites W1980265366 @default.
- W2059126872 cites W1983754832 @default.
- W2059126872 cites W1984414393 @default.
- W2059126872 cites W1984588551 @default.
- W2059126872 cites W1986756809 @default.
- W2059126872 cites W1987799591 @default.
- W2059126872 cites W1989810757 @default.
- W2059126872 cites W1989926395 @default.
- W2059126872 cites W1990445105 @default.
- W2059126872 cites W1992439664 @default.
- W2059126872 cites W1993707487 @default.
- W2059126872 cites W1994244664 @default.
- W2059126872 cites W1994292998 @default.
- W2059126872 cites W1995205013 @default.
- W2059126872 cites W2000916591 @default.
- W2059126872 cites W2006815921 @default.
- W2059126872 cites W2011361041 @default.
- W2059126872 cites W2012995243 @default.
- W2059126872 cites W2015856462 @default.
- W2059126872 cites W2018403116 @default.
- W2059126872 cites W2019673607 @default.
- W2059126872 cites W2022841908 @default.
- W2059126872 cites W2023108832 @default.
- W2059126872 cites W2025056086 @default.
- W2059126872 cites W2034516005 @default.
- W2059126872 cites W2037131305 @default.
- W2059126872 cites W2041746586 @default.
- W2059126872 cites W2042161082 @default.
- W2059126872 cites W2043753178 @default.
- W2059126872 cites W2043839521 @default.
- W2059126872 cites W2045994102 @default.
- W2059126872 cites W2046530404 @default.
- W2059126872 cites W2046693139 @default.
- W2059126872 cites W2049080536 @default.
- W2059126872 cites W2050152653 @default.
- W2059126872 cites W2050310941 @default.
- W2059126872 cites W2050581353 @default.
- W2059126872 cites W2051686420 @default.
- W2059126872 cites W2053071903 @default.
- W2059126872 cites W2053549636 @default.
- W2059126872 cites W2053770731 @default.
- W2059126872 cites W2055047003 @default.
- W2059126872 cites W2056546282 @default.
- W2059126872 cites W2056607057 @default.
- W2059126872 cites W2056908604 @default.
- W2059126872 cites W2058349560 @default.
- W2059126872 cites W2058557461 @default.
- W2059126872 cites W2061879991 @default.
- W2059126872 cites W2062032373 @default.
- W2059126872 cites W2063136699 @default.
- W2059126872 cites W2063716341 @default.
- W2059126872 cites W2064494420 @default.
- W2059126872 cites W2065622820 @default.
- W2059126872 cites W2072245525 @default.
- W2059126872 cites W2076663174 @default.
- W2059126872 cites W2077794733 @default.
- W2059126872 cites W2079113080 @default.
- W2059126872 cites W2081603767 @default.
- W2059126872 cites W2082319788 @default.
- W2059126872 cites W2083556882 @default.
- W2059126872 cites W2083651501 @default.
- W2059126872 cites W2084548757 @default.
- W2059126872 cites W2090480181 @default.
- W2059126872 cites W2091646105 @default.
- W2059126872 cites W2093005831 @default.
- W2059126872 cites W2097298436 @default.
- W2059126872 cites W2097404490 @default.
- W2059126872 cites W2101249156 @default.
- W2059126872 cites W2103824935 @default.
- W2059126872 cites W2104284349 @default.
- W2059126872 cites W2105276495 @default.