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• W2059128417 endingPage "754" @default.
• W2059128417 startingPage "745" @default.
• W2059128417 abstract "We examined the effects of the administration of milnacipran, a dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline uptake on the 5-HT output in rat brain. Local milnacipran administration increased the 5-HT output in frontal cortex and the midbrain raphe nuclei 7- and 10-fold by a Ca(2+)- and tetrodotoxin-dependent mechanism. However, the subcutaneous administration of milnacipran (1-60 mg/kg s.c.) elevated the 5-HT output much less in these areas (200-230% of baseline at 60 mg/kg). In hypothalamus, 10 mg/kg s.c. raised 5-HT levels to 170%. The 5-HT1A antagonist WAY-100635 caused a small potentiation of the effects of milnacipran. The baseline 5-HT output was unaffected by 2-week treatments with milnacipran (30 and 60 mg/kg.day). The distinct regional profile and the lack of enhancement of its effects by WAY-100635 and prolonged treatment suggest that milnacipran does not exert its antidepressant action through an enhancement of the serotonergic function." @default.
• W2059128417 created "2016-06-24" @default.
• W2059128417 creator A5004747167 @default.
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• W2059128417 date "1999-12-01" @default.
• W2059128417 modified "2023-10-06" @default.
• W2059128417 title "Modulation of the Extracellular 5-Hydroxytryptamine Brain Concentrations by the Serotonin and Noradrenaline Reuptake Inhibitor, Milnacipran Microdialysis Studies in Rats" @default.
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• W2059128417 doi "https://doi.org/10.1016/s0893-133x(99)00076-7" @default.
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