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- W2059130536 abstract "Colonies of the HL-60 human leukaemic promyelocytic cell line developing in semisolid agar gel capillaries were established. The endogenous inhibitory fraction GI-3, specific for myeloid cells, hydrocortisone and adriamycin decreased colony number in a dose dependent manner. ED50 values amounted to 220, 10(-1) and 4.5 X 10(-3), micrograms/ml respectively. If administered in combination, the endogenous inhibitor, steroid hormone and cytostatic agent exhibited a marked synergism. They affected HL-60 cells additively, and in some cases, a slight potentiation occurred. The experiments demonstrate the possibility of augmenting the inhibitory activity of cytostatics and hormones on leukaemic cells by endogenous inhibitors without an increase in drug toxicity." @default.
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- W2059130536 date "1985-03-01" @default.
- W2059130536 modified "2023-09-26" @default.
- W2059130536 title "HL-60 human leukaemic cell line colonies in agar capillaries: Comparison of their reactivity to hormones, cytostatics and selective inhibitors of proliferation" @default.
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- W2059130536 doi "https://doi.org/10.1016/0309-1651(85)90036-0" @default.
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