FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059136670> ?p ?o ?g. }

• W2059136670 endingPage "2607" @default.
• W2059136670 startingPage "2600" @default.
• W2059136670 abstract "Drug development in oncology is faced with the challenge of making active new compounds available for standard of care in the shortest possible time frame. While rules and regulations create an accepted factor in delaying trial execution, protocol issues and procedures are more often a delay factor than needed, particularly in industry-sponsored studies. This provides an option to decrease trial time, without affecting patient safety. Among the possible rooms for improvement are a balanced use of in- and exclusion criteria, justified by animal toxicology, and flexible dose escalation steps still defined a priori. It is also of crucial importance to make sure in the phase I programme that the pharmacology of the agent involved is appropriately understood. Including real-time pharmacokinetics, food-effect studies and, if possible, bioavailability studies in the phase I programme would decrease the risk of taking the wrong decisions for follow-on development. The concept of increasing the number of study sites to speed up accrual has a negative effect on trial execution and is actually a delay factor that in addition has the intrinsic risk of putting patient safety at stake." @default.
• W2059136670 created "2016-06-24" @default.
• W2059136670 creator A5011819733 @default.
• W2059136670 date "2008-11-01" @default.
• W2059136670 modified "2023-09-25" @default.
• W2059136670 title "‘No risk, no fun’: Challenges for the oncology phase I clinical trial time-performance" @default.
• W2059136670 cites W1483265830 @default.
• W2059136670 cites W1987301448 @default.
• W2059136670 cites W1987601068 @default.
• W2059136670 cites W200995726 @default.
• W2059136670 cites W2013823405 @default.
• W2059136670 cites W2045541951 @default.
• W2059136670 cites W2068795211 @default.
• W2059136670 cites W2074839878 @default.
• W2059136670 cites W2082504433 @default.
• W2059136670 cites W2096054130 @default.
• W2059136670 cites W2115330997 @default.
• W2059136670 cites W2118342205 @default.
• W2059136670 cites W2140081776 @default.
• W2059136670 cites W2141157727 @default.
• W2059136670 cites W2142752401 @default.
• W2059136670 cites W2149626936 @default.
• W2059136670 cites W2157345824 @default.
• W2059136670 cites W2164956805 @default.
• W2059136670 cites W2165760078 @default.
• W2059136670 cites W2166259130 @default.
• W2059136670 cites W2171492233 @default.
• W2059136670 cites W2240881812 @default.
• W2059136670 cites W2244100803 @default.
• W2059136670 cites W2249555799 @default.
• W2059136670 cites W2255307893 @default.
• W2059136670 cites W2338621439 @default.
• W2059136670 cites W2510726666 @default.
• W2059136670 cites W2590538210 @default.
• W2059136670 cites W2604715670 @default.
• W2059136670 doi "https://doi.org/10.1016/j.ejca.2008.07.043" @default.
• W2059136670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18951015" @default.
• W2059136670 hasPublicationYear "2008" @default.
• W2059136670 type Work @default.
• W2059136670 sameAs 2059136670 @default.
• W2059136670 citedByCount "12" @default.
• W2059136670 countsByYear W20591366702012 @default.
• W2059136670 countsByYear W20591366702013 @default.
• W2059136670 countsByYear W20591366702014 @default.
• W2059136670 countsByYear W20591366702023 @default.
• W2059136670 crossrefType "journal-article" @default.
• W2059136670 hasAuthorship W2059136670A5011819733 @default.
• W2059136670 hasConcept C112930515 @default.
• W2059136670 hasConcept C121955636 @default.
• W2059136670 hasConcept C126322002 @default.
• W2059136670 hasConcept C127413603 @default.
• W2059136670 hasConcept C142724271 @default.
• W2059136670 hasConcept C144133560 @default.
• W2059136670 hasConcept C177713679 @default.
• W2059136670 hasConcept C178790620 @default.
• W2059136670 hasConcept C185592680 @default.
• W2059136670 hasConcept C204787440 @default.
• W2059136670 hasConcept C21547014 @default.
• W2059136670 hasConcept C2780035454 @default.
• W2059136670 hasConcept C2780385302 @default.
• W2059136670 hasConcept C2781426361 @default.
• W2059136670 hasConcept C44280652 @default.
• W2059136670 hasConcept C4577558 @default.
• W2059136670 hasConcept C535046627 @default.
• W2059136670 hasConcept C64903051 @default.
• W2059136670 hasConcept C71924100 @default.
• W2059136670 hasConcept C98274493 @default.
• W2059136670 hasConceptScore W2059136670C112930515 @default.
• W2059136670 hasConceptScore W2059136670C121955636 @default.
• W2059136670 hasConceptScore W2059136670C126322002 @default.
• W2059136670 hasConceptScore W2059136670C127413603 @default.
• W2059136670 hasConceptScore W2059136670C142724271 @default.
• W2059136670 hasConceptScore W2059136670C144133560 @default.
• W2059136670 hasConceptScore W2059136670C177713679 @default.
• W2059136670 hasConceptScore W2059136670C178790620 @default.
• W2059136670 hasConceptScore W2059136670C185592680 @default.
• W2059136670 hasConceptScore W2059136670C204787440 @default.
• W2059136670 hasConceptScore W2059136670C21547014 @default.
• W2059136670 hasConceptScore W2059136670C2780035454 @default.
• W2059136670 hasConceptScore W2059136670C2780385302 @default.
• W2059136670 hasConceptScore W2059136670C2781426361 @default.
• W2059136670 hasConceptScore W2059136670C44280652 @default.
• W2059136670 hasConceptScore W2059136670C4577558 @default.
• W2059136670 hasConceptScore W2059136670C535046627 @default.
• W2059136670 hasConceptScore W2059136670C64903051 @default.
• W2059136670 hasConceptScore W2059136670C71924100 @default.
• W2059136670 hasConceptScore W2059136670C98274493 @default.
• W2059136670 hasIssue "17" @default.
• W2059136670 hasLocation W20591366701 @default.
• W2059136670 hasLocation W20591366702 @default.
• W2059136670 hasOpenAccess W2059136670 @default.
• W2059136670 hasPrimaryLocation W20591366701 @default.
• W2059136670 hasRelatedWork W1987638628 @default.
• W2059136670 hasRelatedWork W2037318693 @default.
• W2059136670 hasRelatedWork W2071907783 @default.
• W2059136670 hasRelatedWork W2082489269 @default.
• W2059136670 hasRelatedWork W2088663266 @default.
• W2059136670 hasRelatedWork W2418602632 @default.

• next