Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059172386> ?p ?o ?g. }
- W2059172386 endingPage "506" @default.
- W2059172386 startingPage "494" @default.
- W2059172386 abstract "Reactive astrogliosis has long been recognized as a ubiquitous feature of CNS pathologies. Although its roles in CNS pathology are only beginning to be defined, genetic tools are enabling molecular dissection of the functions and mechanisms of reactive astrogliosis in vivo. It is now clear that reactive astrogliosis is not simply an all-or-nothing phenomenon but, rather, is a finely gradated continuum of molecular, cellular, and functional changes that range from subtle alterations in gene expression to scar formation. These changes can exert both beneficial and detrimental effects in a context-dependent manner determined by specific molecular signaling cascades. Dysfunction of either astrocytes or the process of reactive astrogliosis is emerging as an important potential source of mechanisms that might contribute to, or play primary roles in, a host of CNS disorders via loss of normal or gain of abnormal astrocyte activities. A rapidly growing understanding of the mechanisms underlying astrocyte signaling and reactive astrogliosis has the potential to open doors to identifying many molecules that might serve as novel therapeutic targets for a wide range of neurological disorders. This review considers general principles and examines selected examples regarding the potential of targeting specific molecular aspects of reactive astrogliosis for therapeutic manipulations, including regulation of glutamate, reactive oxygen species, and cytokines." @default.
- W2059172386 created "2016-06-24" @default.
- W2059172386 creator A5009669991 @default.
- W2059172386 creator A5011858801 @default.
- W2059172386 date "2010-10-01" @default.
- W2059172386 modified "2023-10-02" @default.
- W2059172386 title "Reactive astrocytes as therapeutic targets for CNS disorders" @default.
- W2059172386 cites W1500755288 @default.
- W2059172386 cites W1506745232 @default.
- W2059172386 cites W1530199299 @default.
- W2059172386 cites W1531305298 @default.
- W2059172386 cites W1556211232 @default.
- W2059172386 cites W1581723165 @default.
- W2059172386 cites W1600829492 @default.
- W2059172386 cites W1617304195 @default.
- W2059172386 cites W1629107208 @default.
- W2059172386 cites W1667686291 @default.
- W2059172386 cites W172954148 @default.
- W2059172386 cites W1740101348 @default.
- W2059172386 cites W1754891924 @default.
- W2059172386 cites W1942154378 @default.
- W2059172386 cites W1964053234 @default.
- W2059172386 cites W1965425054 @default.
- W2059172386 cites W1966404127 @default.
- W2059172386 cites W1969373337 @default.
- W2059172386 cites W1969619562 @default.
- W2059172386 cites W1970549117 @default.
- W2059172386 cites W1971639674 @default.
- W2059172386 cites W1973531097 @default.
- W2059172386 cites W1974162725 @default.
- W2059172386 cites W1975545029 @default.
- W2059172386 cites W1976144584 @default.
- W2059172386 cites W1976601635 @default.
- W2059172386 cites W1978916589 @default.
- W2059172386 cites W1979228875 @default.
- W2059172386 cites W1979781669 @default.
- W2059172386 cites W1980132630 @default.
- W2059172386 cites W1980591250 @default.
- W2059172386 cites W1981893433 @default.
- W2059172386 cites W1982007787 @default.
- W2059172386 cites W1982196927 @default.
- W2059172386 cites W1983166842 @default.
- W2059172386 cites W1983861951 @default.
- W2059172386 cites W1983968962 @default.
- W2059172386 cites W1984511547 @default.
- W2059172386 cites W1986637935 @default.
- W2059172386 cites W1988065251 @default.
- W2059172386 cites W1988492454 @default.
- W2059172386 cites W1992509114 @default.
- W2059172386 cites W1994600093 @default.
- W2059172386 cites W1995270458 @default.
- W2059172386 cites W1996277745 @default.
- W2059172386 cites W1996964516 @default.
- W2059172386 cites W1998432972 @default.
- W2059172386 cites W1999495459 @default.
- W2059172386 cites W2002037377 @default.
- W2059172386 cites W2006395355 @default.
- W2059172386 cites W2008079260 @default.
- W2059172386 cites W2008831180 @default.
- W2059172386 cites W2009308901 @default.
- W2059172386 cites W2009517899 @default.
- W2059172386 cites W2011343276 @default.
- W2059172386 cites W2011718960 @default.
- W2059172386 cites W2012676625 @default.
- W2059172386 cites W2012851706 @default.
- W2059172386 cites W2014874816 @default.
- W2059172386 cites W2017081112 @default.
- W2059172386 cites W2017119427 @default.
- W2059172386 cites W2017224849 @default.
- W2059172386 cites W2017277051 @default.
- W2059172386 cites W2018362056 @default.
- W2059172386 cites W2019789113 @default.
- W2059172386 cites W2020026965 @default.
- W2059172386 cites W2020138925 @default.
- W2059172386 cites W2022516974 @default.
- W2059172386 cites W2026674733 @default.
- W2059172386 cites W2028617662 @default.
- W2059172386 cites W2029549981 @default.
- W2059172386 cites W2030356017 @default.
- W2059172386 cites W2031075138 @default.
- W2059172386 cites W2031434196 @default.
- W2059172386 cites W2031479105 @default.
- W2059172386 cites W2032123628 @default.
- W2059172386 cites W2033537576 @default.
- W2059172386 cites W2033833500 @default.
- W2059172386 cites W2034420564 @default.
- W2059172386 cites W2034800617 @default.
- W2059172386 cites W2036679871 @default.
- W2059172386 cites W2038471736 @default.
- W2059172386 cites W2039631987 @default.
- W2059172386 cites W2039779463 @default.
- W2059172386 cites W2039940868 @default.
- W2059172386 cites W2040678584 @default.
- W2059172386 cites W2041976197 @default.
- W2059172386 cites W2043815799 @default.
- W2059172386 cites W2045647567 @default.
- W2059172386 cites W2046400378 @default.
- W2059172386 cites W2046411097 @default.