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- W2059173812 abstract "Differential scanning calorimetry was used to evaluate the interactions between ergotamine tartrate and caffeine. Physical mixtures of ergotamine tartrate and caffeine, as well as mixtures formed by evaporation of ergotamine tartrate and caffeine from a methanol solution, were evaluated. The preparation and characterization of eleven different molar ratios of ergotamine tartrate-caffeine complexes is described. The drug was found to interact with caffeine in the solid state with the formation of complexes. The mixture obtained from the methanol solution showed complexes with ergotamine tartrate-caffeine molar ratios of 2:3 and 2:15, with possible complexes having 1:10, 1:15 and 1:20 molar ratios. A phase diagram was constructed. Physical mixtures of the same molar ratios showed possible complex formation at molar ratios of 1:1, 1:1 and 1:3." @default.
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- W2059173812 date "1983-01-01" @default.
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- W2059173812 title "Studies of Ergotamine Tartrate-Caffeine Interactions by Differential Scanning Calorimetry" @default.
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- W2059173812 doi "https://doi.org/10.3109/03639048309044687" @default.
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