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• W2059180568 abstract "Ferritin is a protein containing about 20 % by weight of iron in the form of a micelle of ferric hydroxide: this is surrounded by a shell of apoferritin. The iron can be removed and the apoferritin crystallised as colourless octahedra similar to the brown octahedral crystals formed by ferritin. An X-ray study has been made of horse spleen apoferritin and of two crystalline forms of ferritin A and B from the same source. Apoferritin and ferritin B crystals are isotropic, while those of ferritin A are anisotropic. All three crystals have identical lattice repeats; wet crystals of apoferritin and ferritin B are face-centred cubic with a = 184 Å, while ferritin A is only pseudo-cubic, being truly face-centred on only one face. The lattice of ferritin A can therefore be described in terms of an orthorhombic unit cell with a = 130 Å, b = 130 Å, c = 184 Å. None of the space-groups are determined unambiguously from the X-ray data, but depend on the exact configurations of the molecules. The space group of apoferritin is probably F432, the unit cell containing four molecules. This being the case each molecule should have point group symmetry 432, and hence be composed of 24n identical sub-units, where n is an integer. A possible molecular structure is suggested, that of 24 sub-units situated at the vertices of a snub-cube. In ferritin B the protein structure is probably identical with that of apoferritin, but point groups 432, 43m or m3m are allowable for the iron hydroxide micelle. If, as suggested by electron microscopy, the micelle consists of four particles at the vertices of a tetrahedron, or eight particles at the vertices of a cube, then each of these particles is probably composed of three sub-units. The possibility that the observed symmetries of apoferritin and ferritin B are produced statistically is also discussed briefly. The X-ray data for ferritin A are consistent with the molecules containing a single two-fold axis, the space group of the orthorhombic unit cell being P21212, P21221 or P22121. Thus either there are two species of ferritin in which the micelles are oriented differently with respect to the protein, or the lattice of ferritin A does not use the full symmetry of the molecule. A molecular diameter of 111–112 Å is derived for apoferritin and ferritin A, the air-dried crystals having a face-centred cubic arrangement with a respectively 158 Å and 156 Å. A molecular weight of 747,000 is obtained for ferritin A. If certain assumptions are made, a molecular weight close to that obtained from sedimentation-diffusion studies can be calculated for apoferritin." @default.
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• W2059180568 date "1959-04-01" @default.
• W2059180568 modified "2023-09-23" @default.
• W2059180568 title "The structures of ferritin and apoferritin: Some preliminary X-ray data" @default.
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• W2059180568 doi "https://doi.org/10.1016/s0022-2836(59)80009-7" @default.
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