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- W2059184991 abstract "Short chain peptides -past and present questions Six years ago, in 1984, many of us had the privilege of attending the first ESPEN-AJINOMOTO Research Symposium here in Hotel Atlantic. On that occasion I was asked to introduce the session devoted to a novel topic peptides. I recall the commencement of my presentation: ‘. . . Peptides might be considered as brand new candidates for parenteral nutrition. Their potential use is based on the assumption that ‘tailored’ amino-acid solutions will increase the benefits of intravenous nutrition for specific patient groups. Undoubtedly this new approach has introduced a new dimension, though the explosion of new information about peptide assimilation is only a prelude to intravenous use of peptides in common clinical practice . .’ (1). I closed my lecture with the statement: ‘. . . in the light of the many important unresolved questions, some of which have been emphasised in this presentation, it must be stressed that studies in healthy and diseased man are urgently required before the use of peptides in parenteral nutrition can be established. Thus, it now appears that this novel form of therapy must await increased fundamental knowledge . . .’ (1). Indeed, during the last 6 years, the great interest directed towards peptide research is mirrored by the numerous publications on peptide synthesis and characterisation as well as relative to their in vivo uptake and subsequent utilisation. Considering the present and past problems I suggest three important topics of interest. The first is the availability of suitable peptides. They should be highly soluble and stable during sterilisation procedures. In addition, they must be sufficiently pure to be included in parenteral solutions. The second relates to human studies in healthy volunteers and stressed or malnourished patients. Thirdly, in vivo peptide handling might be of great interest when examining the capacity for and efficacy of utilisation as well as the affinity for hydrolysis of the individual peptides." @default.
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- W2059184991 date "1991-01-01" @default.
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- W2059184991 title "Peptides in clinical nutrition" @default.
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- W2059184991 doi "https://doi.org/10.1016/0261-5614(91)90110-x" @default.
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