Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059189197> ?p ?o ?g. }
- W2059189197 endingPage "1057" @default.
- W2059189197 startingPage "1051" @default.
- W2059189197 abstract "To study the role of 5-HT2A and 5-HT2C receptor subtypes in anxiety, the behavioral effects of drugs that either block or stimulate these receptors were measured in an animal model of anxiety, the elevated T-maze. One arm of the maze is enclosed by walls and stands perpendicular to the two open arms. Inhibitory (passive) avoidance--representing learned fear--was measured by placing a rat at the end of the enclosed arm and recording the time to leave this arm with the four paws during three consecutive trials. After 30 s, the same animal was placed at the end of one of the open arms and the time to leave this arm with the four paws was recorded. This one-way escape response represents unconditioned fear. The I.P. injection of the preferential 5-HT2C receptor agonists mCPP and TFMPP (0.1-0.8 mg/kg), 25 min before the experimental session enhanced inhibitory avoidance. In contrast, the same drugs either tended to impair (mCPP) or significantly inhibited (TFMPP) one-way escape. The preferential 5-HT2A agonist DOI (0.03-0.3 mg/kg) did not change either inhibitory avoidance or one-way escape. Inhibitory avoidance was impaired by the selective 5-HT2C antagonists SB 200646A (3.0-30 mg/kg) and SDZ SER 082 (0.1-1.0 mg/kg), by the 5-HT2A antagonist SR 46349B (1.0-10.0 mg/kg), and by the mixed 5-HT(2A,2C) antagonist ritanserin (0.3-3.0 mg/kg). However, it was not affected by the selective 5-HT2A antagonist RP 62203 (0.25-4.0 mg/kg). All the 5-HT2 antagonists used were ineffective on one-way escape. Therefore, conditioned fear seems to be tonically facilitated through 5-HT2C receptor stimulation, although the 5-HT2A receptor may also participate in its regulation. Unconditioned fear might be phasically inhibited by 5-HT2C receptor activation." @default.
- W2059189197 created "2016-06-24" @default.
- W2059189197 creator A5042279715 @default.
- W2059189197 creator A5063297653 @default.
- W2059189197 creator A5075240617 @default.
- W2059189197 date "1997-12-01" @default.
- W2059189197 modified "2023-09-27" @default.
- W2059189197 title "Role of 5-HT2A and 5-HT2C Receptor Subtypes in the Two Types of Fear Generated by the Elevated T-Maze" @default.
- W2059189197 cites W1589045539 @default.
- W2059189197 cites W1881562135 @default.
- W2059189197 cites W1977142623 @default.
- W2059189197 cites W1984470666 @default.
- W2059189197 cites W2003125564 @default.
- W2059189197 cites W2003686526 @default.
- W2059189197 cites W2007011615 @default.
- W2059189197 cites W2016189630 @default.
- W2059189197 cites W2016336988 @default.
- W2059189197 cites W2025678690 @default.
- W2059189197 cites W2026645313 @default.
- W2059189197 cites W2032888432 @default.
- W2059189197 cites W2033967523 @default.
- W2059189197 cites W2038361574 @default.
- W2059189197 cites W2041457090 @default.
- W2059189197 cites W2044799822 @default.
- W2059189197 cites W2056575770 @default.
- W2059189197 cites W2061208136 @default.
- W2059189197 cites W2065647990 @default.
- W2059189197 cites W2070989445 @default.
- W2059189197 cites W2078312844 @default.
- W2059189197 cites W2079458732 @default.
- W2059189197 cites W2088945268 @default.
- W2059189197 cites W2094417837 @default.
- W2059189197 cites W2147281759 @default.
- W2059189197 cites W2161630761 @default.
- W2059189197 cites W2331337476 @default.
- W2059189197 cites W4251513029 @default.
- W2059189197 doi "https://doi.org/10.1016/s0091-3057(97)00057-9" @default.
- W2059189197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9408213" @default.
- W2059189197 hasPublicationYear "1997" @default.
- W2059189197 type Work @default.
- W2059189197 sameAs 2059189197 @default.
- W2059189197 citedByCount "81" @default.
- W2059189197 countsByYear W20591891972012 @default.
- W2059189197 countsByYear W20591891972013 @default.
- W2059189197 countsByYear W20591891972014 @default.
- W2059189197 countsByYear W20591891972015 @default.
- W2059189197 countsByYear W20591891972016 @default.
- W2059189197 countsByYear W20591891972018 @default.
- W2059189197 countsByYear W20591891972020 @default.
- W2059189197 countsByYear W20591891972021 @default.
- W2059189197 countsByYear W20591891972022 @default.
- W2059189197 countsByYear W20591891972023 @default.
- W2059189197 crossrefType "journal-article" @default.
- W2059189197 hasAuthorship W2059189197A5042279715 @default.
- W2059189197 hasAuthorship W2059189197A5063297653 @default.
- W2059189197 hasAuthorship W2059189197A5075240617 @default.
- W2059189197 hasConcept C118552586 @default.
- W2059189197 hasConcept C126322002 @default.
- W2059189197 hasConcept C134018914 @default.
- W2059189197 hasConcept C15744967 @default.
- W2059189197 hasConcept C169760540 @default.
- W2059189197 hasConcept C170493617 @default.
- W2059189197 hasConcept C17077164 @default.
- W2059189197 hasConcept C173586616 @default.
- W2059189197 hasConcept C185592680 @default.
- W2059189197 hasConcept C2775864247 @default.
- W2059189197 hasConcept C2776885963 @default.
- W2059189197 hasConcept C2777450907 @default.
- W2059189197 hasConcept C2778122271 @default.
- W2059189197 hasConcept C2778539182 @default.
- W2059189197 hasConcept C2778938600 @default.
- W2059189197 hasConcept C53910766 @default.
- W2059189197 hasConcept C558461103 @default.
- W2059189197 hasConcept C71924100 @default.
- W2059189197 hasConcept C98274493 @default.
- W2059189197 hasConceptScore W2059189197C118552586 @default.
- W2059189197 hasConceptScore W2059189197C126322002 @default.
- W2059189197 hasConceptScore W2059189197C134018914 @default.
- W2059189197 hasConceptScore W2059189197C15744967 @default.
- W2059189197 hasConceptScore W2059189197C169760540 @default.
- W2059189197 hasConceptScore W2059189197C170493617 @default.
- W2059189197 hasConceptScore W2059189197C17077164 @default.
- W2059189197 hasConceptScore W2059189197C173586616 @default.
- W2059189197 hasConceptScore W2059189197C185592680 @default.
- W2059189197 hasConceptScore W2059189197C2775864247 @default.
- W2059189197 hasConceptScore W2059189197C2776885963 @default.
- W2059189197 hasConceptScore W2059189197C2777450907 @default.
- W2059189197 hasConceptScore W2059189197C2778122271 @default.
- W2059189197 hasConceptScore W2059189197C2778539182 @default.
- W2059189197 hasConceptScore W2059189197C2778938600 @default.
- W2059189197 hasConceptScore W2059189197C53910766 @default.
- W2059189197 hasConceptScore W2059189197C558461103 @default.
- W2059189197 hasConceptScore W2059189197C71924100 @default.
- W2059189197 hasConceptScore W2059189197C98274493 @default.
- W2059189197 hasIssue "4" @default.
- W2059189197 hasLocation W20591891971 @default.
- W2059189197 hasLocation W20591891972 @default.
- W2059189197 hasOpenAccess W2059189197 @default.