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- W2059199582 abstract "Summary Development of sensitive techniques in ageing population and increase of monoclonal gammopathies frequency do not miss to raise medical – economic problems. Capillary electrophoresis and free light chains assays are assessed in this study. Capillary electrophoresis represents a major technological advance for serum immunoglobulins study with very good reproducibility, speed of execution and security even if sensibility and specificity (73.6 and 92% respectively) are slightly weaker than those of agarose gel electrophoresis (79 and 96%). The description of two patients with Ig M paraproteins “false negatives” requires caution. The problem of antigen excess in the free light chains assay encourages in circumspection and shows the necessity of coupling this assay with additional tests. Its use in screening strategy with electrophoresis should not be proposed but its interest is major in diagnosis and monitoring of Bence Jones myeloma, nonsecretory myeloma and AL amyloidosis." @default.
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- W2059199582 date "2008-08-01" @default.
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- W2059199582 title "Apport de l’électrophorèse capillaire et du dosage des chaînes légères libres dans l’exploration des immunoglobulines : le point de vue de l’immunologiste" @default.
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- W2059199582 doi "https://doi.org/10.1016/j.immbio.2008.07.003" @default.
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