Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059200052> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2059200052 endingPage "S29" @default.
- W2059200052 startingPage "S29" @default.
- W2059200052 abstract "Experimental evidence suggests that recommended dosages of some corticosteroids used clinically as antiinflammatory agents for treating arthropathies damage articular cartilage, but low dosages may be chondroprotective. The purpose of this study was to evaluate how different concentrations of methylprednisolone affect chondrocyte function and viability. Articular cartilage and chondrocytes were obtained from young adult horses, 1.5–3.5 years of age. Corticosteroid-induced changes in collagen expression were studied at the transcriptional level by Northern blot analyses and at the translational level by measuring [3H]-proline incorporation into [3H]-hydroxyproline. Fibronectin mRNA splicing patterns were evaluated with ribonuclease protection assays. Cytotoxicity was studied using erythrosin B dye exclusion. Steady-state levels of type II procollagen mRNA decreased without concurrent changes in type I procollagen expression as the medium methylprednisolone concentrations were increased from 1×101 to 1×108 pg/ml, dropping below 10% of control values by 1×105 pg/ml. Cytotoxicity occurred as methylprednisolone levels were increased further from 1×108 to 1×109 pg/ml. Changes in total collagen (protein) synthesis were less pronounced, but also demonstrated significant suppression between 1×104 and 1×108 pg/ml. Corticosteroid-induced changes in fibronectin isoform levels were evaluated in articular cartilage samples without in vitro culture. The cartilage-specific (V+C)− isoform was suppressed in both normal and inflamed joints by a single intraarticular injection (0.1 mg/kg) of methylprednisolone. Combined, these data indicate that methylprednisolone suppresses matrix protein markers of chondrocytic differentiation. Decreased and altered chondrocyte expression of matrix proteins likely contributes to the pathogenesis of corticosteroid-induced cartilage degeneration." @default.
- W2059200052 created "2016-06-24" @default.
- W2059200052 creator A5006408935 @default.
- W2059200052 creator A5038782423 @default.
- W2059200052 creator A5069207900 @default.
- W2059200052 creator A5076170112 @default.
- W2059200052 creator A5077750831 @default.
- W2059200052 date "2008-11-01" @default.
- W2059200052 modified "2023-09-27" @default.
- W2059200052 title "O56 Efficacy of Diacerin (™Diasol) in patients with symptomatic OA knees: results from a 24 week open label study" @default.
- W2059200052 doi "https://doi.org/10.1016/s0973-3698(10)60430-x" @default.
- W2059200052 hasPublicationYear "2008" @default.
- W2059200052 type Work @default.
- W2059200052 sameAs 2059200052 @default.
- W2059200052 citedByCount "0" @default.
- W2059200052 crossrefType "journal-article" @default.
- W2059200052 hasAuthorship W2059200052A5006408935 @default.
- W2059200052 hasAuthorship W2059200052A5038782423 @default.
- W2059200052 hasAuthorship W2059200052A5069207900 @default.
- W2059200052 hasAuthorship W2059200052A5076170112 @default.
- W2059200052 hasAuthorship W2059200052A5077750831 @default.
- W2059200052 hasBestOaLocation W20592000521 @default.
- W2059200052 hasConcept C104317684 @default.
- W2059200052 hasConcept C105580179 @default.
- W2059200052 hasConcept C105702510 @default.
- W2059200052 hasConcept C109316439 @default.
- W2059200052 hasConcept C126322002 @default.
- W2059200052 hasConcept C134018914 @default.
- W2059200052 hasConcept C153911025 @default.
- W2059200052 hasConcept C162156334 @default.
- W2059200052 hasConcept C16685009 @default.
- W2059200052 hasConcept C185592680 @default.
- W2059200052 hasConcept C189165786 @default.
- W2059200052 hasConcept C202751555 @default.
- W2059200052 hasConcept C203014093 @default.
- W2059200052 hasConcept C2776415932 @default.
- W2059200052 hasConcept C2776804153 @default.
- W2059200052 hasConcept C2779797417 @default.
- W2059200052 hasConcept C2780372218 @default.
- W2059200052 hasConcept C2780550940 @default.
- W2059200052 hasConcept C2781403057 @default.
- W2059200052 hasConcept C2909889181 @default.
- W2059200052 hasConcept C55493867 @default.
- W2059200052 hasConcept C64348721 @default.
- W2059200052 hasConcept C71924100 @default.
- W2059200052 hasConcept C86492073 @default.
- W2059200052 hasConcept C86803240 @default.
- W2059200052 hasConceptScore W2059200052C104317684 @default.
- W2059200052 hasConceptScore W2059200052C105580179 @default.
- W2059200052 hasConceptScore W2059200052C105702510 @default.
- W2059200052 hasConceptScore W2059200052C109316439 @default.
- W2059200052 hasConceptScore W2059200052C126322002 @default.
- W2059200052 hasConceptScore W2059200052C134018914 @default.
- W2059200052 hasConceptScore W2059200052C153911025 @default.
- W2059200052 hasConceptScore W2059200052C162156334 @default.
- W2059200052 hasConceptScore W2059200052C16685009 @default.
- W2059200052 hasConceptScore W2059200052C185592680 @default.
- W2059200052 hasConceptScore W2059200052C189165786 @default.
- W2059200052 hasConceptScore W2059200052C202751555 @default.
- W2059200052 hasConceptScore W2059200052C203014093 @default.
- W2059200052 hasConceptScore W2059200052C2776415932 @default.
- W2059200052 hasConceptScore W2059200052C2776804153 @default.
- W2059200052 hasConceptScore W2059200052C2779797417 @default.
- W2059200052 hasConceptScore W2059200052C2780372218 @default.
- W2059200052 hasConceptScore W2059200052C2780550940 @default.
- W2059200052 hasConceptScore W2059200052C2781403057 @default.
- W2059200052 hasConceptScore W2059200052C2909889181 @default.
- W2059200052 hasConceptScore W2059200052C55493867 @default.
- W2059200052 hasConceptScore W2059200052C64348721 @default.
- W2059200052 hasConceptScore W2059200052C71924100 @default.
- W2059200052 hasConceptScore W2059200052C86492073 @default.
- W2059200052 hasConceptScore W2059200052C86803240 @default.
- W2059200052 hasIssue "3" @default.
- W2059200052 hasLocation W20592000521 @default.
- W2059200052 hasOpenAccess W2059200052 @default.
- W2059200052 hasPrimaryLocation W20592000521 @default.
- W2059200052 hasRelatedWork W1964997366 @default.
- W2059200052 hasRelatedWork W1980437875 @default.
- W2059200052 hasRelatedWork W2049047086 @default.
- W2059200052 hasRelatedWork W2060397124 @default.
- W2059200052 hasRelatedWork W2062823318 @default.
- W2059200052 hasRelatedWork W2074582172 @default.
- W2059200052 hasRelatedWork W2090247958 @default.
- W2059200052 hasRelatedWork W2123410636 @default.
- W2059200052 hasRelatedWork W2401879344 @default.
- W2059200052 hasRelatedWork W2418595968 @default.
- W2059200052 hasVolume "3" @default.
- W2059200052 isParatext "false" @default.
- W2059200052 isRetracted "false" @default.
- W2059200052 magId "2059200052" @default.
- W2059200052 workType "article" @default.