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• W2059201346 abstract "Prokineticin 2 (PROK2) is a secreted protein that regulates diverse biological processes including olfactory bulb neurogenesis in adult mammals. However, its precise role in this process is as yet not fully understood. Because it is well known that adult teleost fish, including zebrafish, display an intense proliferative activity in several brain regions, we took advantage of this feature to analyze the distribution of PROK2 transcripts in the adult zebrafish brain and during injury-induced telencephalon (TC) regeneration. First, we characterized the zebrafish PROK2 gene and showed that its transcription takes place in almost all proliferating areas previously identified in adult zebrafish brain. Moreover, in TC, PROK2 transcription was mainly restricted to neurons. Next, using a novel model of TC injury in adult zebrafish, we observed that TC lesion induced a dramatic increase in cell proliferation within the injured hemisphere in regions located both adjacent and distal to injury sites. Moreover, our data strongly suggest that cell proliferation was followed by the migration of newly generated neurons toward injury sites. In addition, we observed a transient over-expression of PROK2 transcripts, which was detected in cells surrounding the lesion during the very first days post injury, and, a few days later, in broad cell rows extending from cortical regions of the TC toward injury sites. PROK2 over-expression was no longer detected when the regeneration process was close to completion, showing that ectopic PROK2 transcription paralleled neuronal regeneration. Taken together, our results suggest that in adult zebrafish brain, PROK2 may play a role in both constitutive and injury-induced neurogenesis." @default.
• W2059201346 created "2016-06-24" @default.
• W2059201346 creator A5001381975 @default.
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• W2059201346 date "2010-05-01" @default.
• W2059201346 modified "2023-10-16" @default.
• W2059201346 title "Prokineticin 2 Expression Is Associated with Neural Repair of Injured Adult Zebrafish Telencephalon" @default.
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• W2059201346 doi "https://doi.org/10.1089/neu.2009.0972" @default.
• W2059201346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20102264" @default.
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