FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059204108> ?p ?o ?g. }

• W2059204108 endingPage "795" @default.
• W2059204108 startingPage "s783" @default.
• W2059204108 abstract "Evidence suggests that monocyte adhesion to endothelial cells as well as excessive proliferation and migration of vascular smooth muscle cells (VSMC) are key events in the development of atherosclerosis and restenosis after balloon angioplasty. These processes are mainly mediated by growth factors, inflammatory cytokines, chemokines and related factors released by various cells in the vessel wall. The mechanisms of action of these factors are however not very clear. These growth factors and cytokines acting on VSMC and endothelial cells can activate phospholipases with the release of lipids such as arachidonic and linoleic acids. These lipids can be further metabolized by several pathways including the lipoxygenase (LO) pathway. These oxidative pathways can lead to the formation of free radicals and lipid peroxides. LO products have been shown to have potent inflammatory, growth, adhesive and chemoattractant effects in cells. They are also associated with oxidant stress and cellular apoptosis. This chapter reviews the role and mechanisms of action of the LO pathway and its products in the pathogenesis of cardiovascular diseases and diabetic vascular complications. The importance of the leukocyte 12/15-LO in the pathology of these disorders is suggested by studies in which the 12/15-LO null mice displayed attenuated atherosclerosis. Activation of the LO pathway along with associated oxidant stress and signaling pathways may be a common mechanism shared by growth factors and cytokines in leading to increased inflammatory and proliferative disorders, including those associated with atherosclerosis, hypertension and related diabetic vascular complications." @default.
• W2059204108 created "2016-06-24" @default.
• W2059204108 creator A5044566437 @default.
• W2059204108 date "2003-01-01" @default.
• W2059204108 modified "2023-10-16" @default.
• W2059204108 title "Lipoxygenases and lipid signaling in vascular cells in diabetes" @default.
• W2059204108 cites W1496561250 @default.
• W2059204108 cites W1519680626 @default.
• W2059204108 cites W1521799099 @default.
• W2059204108 cites W1528340834 @default.
• W2059204108 cites W1533414834 @default.
• W2059204108 cites W1540646729 @default.
• W2059204108 cites W1567124203 @default.
• W2059204108 cites W178002050 @default.
• W2059204108 cites W1856590789 @default.
• W2059204108 cites W1964942556 @default.
• W2059204108 cites W1967032130 @default.
• W2059204108 cites W1970666689 @default.
• W2059204108 cites W1972398016 @default.
• W2059204108 cites W1972484742 @default.
• W2059204108 cites W1975517899 @default.
• W2059204108 cites W1989123782 @default.
• W2059204108 cites W1989683994 @default.
• W2059204108 cites W1992867991 @default.
• W2059204108 cites W1995145529 @default.
• W2059204108 cites W2000912603 @default.
• W2059204108 cites W2002130752 @default.
• W2059204108 cites W2004704496 @default.
• W2059204108 cites W2005115885 @default.
• W2059204108 cites W2006012802 @default.
• W2059204108 cites W2026304372 @default.
• W2059204108 cites W2026973246 @default.
• W2059204108 cites W2027485498 @default.
• W2059204108 cites W2028987088 @default.
• W2059204108 cites W2030453145 @default.
• W2059204108 cites W2039883000 @default.
• W2059204108 cites W2046149557 @default.
• W2059204108 cites W2047033409 @default.
• W2059204108 cites W2048470524 @default.
• W2059204108 cites W2052028692 @default.
• W2059204108 cites W2054233827 @default.
• W2059204108 cites W2054433514 @default.
• W2059204108 cites W2055580224 @default.
• W2059204108 cites W2058645346 @default.
• W2059204108 cites W2066365098 @default.
• W2059204108 cites W2067904160 @default.
• W2059204108 cites W2076707528 @default.
• W2059204108 cites W2081304820 @default.
• W2059204108 cites W2084674353 @default.
• W2059204108 cites W2084997952 @default.
• W2059204108 cites W2087302053 @default.
• W2059204108 cites W2089190393 @default.
• W2059204108 cites W2090651525 @default.
• W2059204108 cites W2091708689 @default.
• W2059204108 cites W2104472761 @default.
• W2059204108 cites W2105839214 @default.
• W2059204108 cites W2105937445 @default.
• W2059204108 cites W2107938935 @default.
• W2059204108 cites W2108014410 @default.
• W2059204108 cites W2108995222 @default.
• W2059204108 cites W2109341538 @default.
• W2059204108 cites W2112187949 @default.
• W2059204108 cites W2115050270 @default.
• W2059204108 cites W2119671768 @default.
• W2059204108 cites W2122020349 @default.
• W2059204108 cites W2126473502 @default.
• W2059204108 cites W2132306888 @default.
• W2059204108 cites W2132658963 @default.
• W2059204108 cites W2133631540 @default.
• W2059204108 cites W2139588799 @default.
• W2059204108 cites W2143543265 @default.
• W2059204108 cites W2156753461 @default.
• W2059204108 cites W2156830520 @default.
• W2059204108 cites W2157677688 @default.
• W2059204108 cites W2159226443 @default.
• W2059204108 cites W2167974856 @default.
• W2059204108 cites W2168996156 @default.
• W2059204108 cites W2178947601 @default.
• W2059204108 cites W2406092523 @default.
• W2059204108 cites W2473854922 @default.
• W2059204108 doi "https://doi.org/10.2741/1144" @default.
• W2059204108 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12957878" @default.
• W2059204108 hasPublicationYear "2003" @default.
• W2059204108 type Work @default.
• W2059204108 sameAs 2059204108 @default.
• W2059204108 citedByCount "50" @default.
• W2059204108 countsByYear W20592041082012 @default.
• W2059204108 countsByYear W20592041082013 @default.
• W2059204108 countsByYear W20592041082014 @default.
• W2059204108 countsByYear W20592041082015 @default.
• W2059204108 countsByYear W20592041082016 @default.
• W2059204108 countsByYear W20592041082017 @default.
• W2059204108 countsByYear W20592041082018 @default.
• W2059204108 countsByYear W20592041082019 @default.
• W2059204108 countsByYear W20592041082020 @default.
• W2059204108 countsByYear W20592041082022 @default.
• W2059204108 countsByYear W20592041082023 @default.
• W2059204108 crossrefType "journal-article" @default.

• next