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• W2059212129 abstract "The remarkable binding properties of LNA (Locked Nucleic Acid) and α-L-LNA (the α-L-ribo configured diastereoisomer of LNA) are summarized, and hybridization results for LNA/2′-O-Me-RNA chimera and LNAs with a “dangling” nucleotide are introduced. In addition, results from NMR investigations on the furanose conformations of the individual nucleotide monomers in different duplexes are presented. All these data are discussed with focus on the importance of conformational steering of unmodified nucleotides in partly modified LNA and α-L-LNA sequences in relation to the unprecedented binding properties of LNA and α-L-LNA." @default.
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• W2059212129 date "2001-03-31" @default.
• W2059212129 modified "2023-09-26" @default.
• W2059212129 title "LNA (LOCKED NUCLEIC ACID) AND THE DIASTEREOISOMERIC α-L-LNA: CONFORMATIONAL TUNING AND HIGH-AFFINITY RECOGNITION OF DNA/RNA TARGETS" @default.
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• W2059212129 doi "https://doi.org/10.1081/ncn-100002312" @default.
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