FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059243373> ?p ?o ?g. }

• W2059243373 endingPage "7490" @default.
• W2059243373 startingPage "7486" @default.
• W2059243373 abstract "Abstract We examined the feasibility of using adeno-associated virus (AAV)-mediated systemic delivery of endostatin in gene therapy to treat metastasis of pancreatic cancer. We established an animal model of orthotopic metastatic pancreatic cancer in which the pancreatic cancer cell line PGHAM-1 was inoculated into the pancreas of Syrian golden hamsters. Transplanted cells proliferated rapidly and metastasized to the liver. An AAV vector expressing endostatin (5 × 1010 particles) was injected intramuscularly into the left quadriceps or intravenously into the portal vein. These routes of vector administration were evaluated by comparing various parameters of tumor development. Intramuscular injection of the vector modestly increased the serum endostatin level. The numbers of metastases and the incidence of hemorrhagic ascites were decreased in the treated animals. In contrast, the serum concentration of endostatin was significantly increased after intraportal injection of the vector. The antitumor effects on all parameters (including the size and microvessel density of primary pancreatic tumors, the sizes and number of liver metastases, and the incidence of hemorrhagic ascites) were significant. These results suggest that systemic delivery of endostatin represents a potentially effective treatment for pancreatic cancer and liver metastases. The route of vector administration influences the efficacy of AAV-mediated endostatin expression. Intraportal injection of the AAV vector appears to be more effective as an antiangiogenic gene therapy for pancreatic cancer." @default.
• W2059243373 created "2016-06-24" @default.
• W2059243373 creator A5023330443 @default.
• W2059243373 creator A5030019495 @default.
• W2059243373 creator A5031450216 @default.
• W2059243373 creator A5037013625 @default.
• W2059243373 creator A5057400638 @default.
• W2059243373 creator A5059992812 @default.
• W2059243373 creator A5065226133 @default.
• W2059243373 creator A5078587168 @default.
• W2059243373 date "2004-10-15" @default.
• W2059243373 modified "2023-10-12" @default.
• W2059243373 title "Adeno-Associated Viral Vector-Mediated Expression of Endostatin Inhibits Tumor Growth and Metastasis in an Orthotropic Pancreatic Cancer Model in Hamsters" @default.
• W2059243373 cites W1512913625 @default.
• W2059243373 cites W1756236371 @default.
• W2059243373 cites W1963623233 @default.
• W2059243373 cites W1967357094 @default.
• W2059243373 cites W1967752426 @default.
• W2059243373 cites W1968431199 @default.
• W2059243373 cites W1978519692 @default.
• W2059243373 cites W1983576689 @default.
• W2059243373 cites W1983903557 @default.
• W2059243373 cites W1984243249 @default.
• W2059243373 cites W1987840976 @default.
• W2059243373 cites W1987854878 @default.
• W2059243373 cites W1991148746 @default.
• W2059243373 cites W2014010760 @default.
• W2059243373 cites W2021742633 @default.
• W2059243373 cites W2024996514 @default.
• W2059243373 cites W2038036971 @default.
• W2059243373 cites W2041196737 @default.
• W2059243373 cites W2050245606 @default.
• W2059243373 cites W2052087785 @default.
• W2059243373 cites W2064644581 @default.
• W2059243373 cites W2071602601 @default.
• W2059243373 cites W2072815621 @default.
• W2059243373 cites W2073308580 @default.
• W2059243373 cites W2081171265 @default.
• W2059243373 cites W2102909017 @default.
• W2059243373 cites W2103607678 @default.
• W2059243373 cites W2121944814 @default.
• W2059243373 cites W2128684337 @default.
• W2059243373 cites W2131798870 @default.
• W2059243373 cites W2143836588 @default.
• W2059243373 cites W2159567933 @default.
• W2059243373 cites W2165815741 @default.
• W2059243373 cites W2172782937 @default.
• W2059243373 doi "https://doi.org/10.1158/0008-5472.can-03-1296" @default.
• W2059243373 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15492274" @default.
• W2059243373 hasPublicationYear "2004" @default.
• W2059243373 type Work @default.
• W2059243373 sameAs 2059243373 @default.
• W2059243373 citedByCount "44" @default.
• W2059243373 countsByYear W20592433732013 @default.
• W2059243373 countsByYear W20592433732014 @default.
• W2059243373 countsByYear W20592433732015 @default.
• W2059243373 countsByYear W20592433732017 @default.
• W2059243373 countsByYear W20592433732018 @default.
• W2059243373 countsByYear W20592433732020 @default.
• W2059243373 countsByYear W20592433732021 @default.
• W2059243373 countsByYear W20592433732022 @default.
• W2059243373 countsByYear W20592433732023 @default.
• W2059243373 crossrefType "journal-article" @default.
• W2059243373 hasAuthorship W2059243373A5023330443 @default.
• W2059243373 hasAuthorship W2059243373A5030019495 @default.
• W2059243373 hasAuthorship W2059243373A5031450216 @default.
• W2059243373 hasAuthorship W2059243373A5037013625 @default.
• W2059243373 hasAuthorship W2059243373A5057400638 @default.
• W2059243373 hasAuthorship W2059243373A5059992812 @default.
• W2059243373 hasAuthorship W2059243373A5065226133 @default.
• W2059243373 hasAuthorship W2059243373A5078587168 @default.
• W2059243373 hasBestOaLocation W20592433731 @default.
• W2059243373 hasConcept C104317684 @default.
• W2059243373 hasConcept C111599444 @default.
• W2059243373 hasConcept C121608353 @default.
• W2059243373 hasConcept C126322002 @default.
• W2059243373 hasConcept C142724271 @default.
• W2059243373 hasConcept C2778764654 @default.
• W2059243373 hasConcept C2779013556 @default.
• W2059243373 hasConcept C2780210213 @default.
• W2059243373 hasConcept C2780394083 @default.
• W2059243373 hasConcept C502942594 @default.
• W2059243373 hasConcept C55493867 @default.
• W2059243373 hasConcept C71924100 @default.
• W2059243373 hasConcept C75920679 @default.
• W2059243373 hasConcept C86803240 @default.
• W2059243373 hasConceptScore W2059243373C104317684 @default.
• W2059243373 hasConceptScore W2059243373C111599444 @default.
• W2059243373 hasConceptScore W2059243373C121608353 @default.
• W2059243373 hasConceptScore W2059243373C126322002 @default.
• W2059243373 hasConceptScore W2059243373C142724271 @default.
• W2059243373 hasConceptScore W2059243373C2778764654 @default.
• W2059243373 hasConceptScore W2059243373C2779013556 @default.
• W2059243373 hasConceptScore W2059243373C2780210213 @default.
• W2059243373 hasConceptScore W2059243373C2780394083 @default.
• W2059243373 hasConceptScore W2059243373C502942594 @default.
• W2059243373 hasConceptScore W2059243373C55493867 @default.
• W2059243373 hasConceptScore W2059243373C71924100 @default.

• next