Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059244811> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2059244811 abstract "It has been reported recently that the U leader exon located within the 5' untranslated region of Epstein-Barr nuclear antigen 1 (EBNA1) gene contains an internal ribosome entry site (IRES) element. Sequence analysis of the U leader exon was undertaken in samples from 19 patients with infectious mononucleosis and 19 patients with lethal lymphoproliferative diseases and in 15 spontaneously established lymphoblastoid cell lines. The sequence was conserved except for a single base substitution (T-C) at position 67,585. Although the mutation was detected in only one case of infectious mononucleosis, it was found in more than half of the lethal lymphoproliferative diseases and all lymphoblastoid cell lines. The results suggest that a mutation in the IRES element affects EBNA1 gene expression at the translational level and provides Epstein-Barr virus (EBV)-infected cells with a growth advantage, leading to immortalization of cells in vitro and to the development of lethal lymphoproliferative diseases in vivo." @default.
- W2059244811 created "2016-06-24" @default.
- W2059244811 creator A5020689274 @default.
- W2059244811 creator A5027543477 @default.
- W2059244811 creator A5029655825 @default.
- W2059244811 creator A5034431719 @default.
- W2059244811 creator A5047298208 @default.
- W2059244811 date "2004-02-13" @default.
- W2059244811 modified "2023-09-27" @default.
- W2059244811 title "Possible involvement in oncogenesis of a single base mutation in an internal ribosome entry site of Epstein–Barr nuclear antigen 1 mRNA" @default.
- W2059244811 doi "https://doi.org/10.1002/jmv.20022" @default.
- W2059244811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14981766" @default.
- W2059244811 hasPublicationYear "2004" @default.
- W2059244811 type Work @default.
- W2059244811 sameAs 2059244811 @default.
- W2059244811 citedByCount "4" @default.
- W2059244811 countsByYear W20592448112013 @default.
- W2059244811 crossrefType "journal-article" @default.
- W2059244811 hasAuthorship W2059244811A5020689274 @default.
- W2059244811 hasAuthorship W2059244811A5027543477 @default.
- W2059244811 hasAuthorship W2059244811A5029655825 @default.
- W2059244811 hasAuthorship W2059244811A5034431719 @default.
- W2059244811 hasAuthorship W2059244811A5047298208 @default.
- W2059244811 hasConcept C104317684 @default.
- W2059244811 hasConcept C105580179 @default.
- W2059244811 hasConcept C147483822 @default.
- W2059244811 hasConcept C149364088 @default.
- W2059244811 hasConcept C153911025 @default.
- W2059244811 hasConcept C159047783 @default.
- W2059244811 hasConcept C2522874641 @default.
- W2059244811 hasConcept C2781375147 @default.
- W2059244811 hasConcept C36823959 @default.
- W2059244811 hasConcept C54355233 @default.
- W2059244811 hasConcept C77430603 @default.
- W2059244811 hasConcept C86803240 @default.
- W2059244811 hasConcept C89604277 @default.
- W2059244811 hasConceptScore W2059244811C104317684 @default.
- W2059244811 hasConceptScore W2059244811C105580179 @default.
- W2059244811 hasConceptScore W2059244811C147483822 @default.
- W2059244811 hasConceptScore W2059244811C149364088 @default.
- W2059244811 hasConceptScore W2059244811C153911025 @default.
- W2059244811 hasConceptScore W2059244811C159047783 @default.
- W2059244811 hasConceptScore W2059244811C2522874641 @default.
- W2059244811 hasConceptScore W2059244811C2781375147 @default.
- W2059244811 hasConceptScore W2059244811C36823959 @default.
- W2059244811 hasConceptScore W2059244811C54355233 @default.
- W2059244811 hasConceptScore W2059244811C77430603 @default.
- W2059244811 hasConceptScore W2059244811C86803240 @default.
- W2059244811 hasConceptScore W2059244811C89604277 @default.
- W2059244811 hasLocation W20592448111 @default.
- W2059244811 hasLocation W20592448112 @default.
- W2059244811 hasOpenAccess W2059244811 @default.
- W2059244811 hasPrimaryLocation W20592448111 @default.
- W2059244811 hasRelatedWork W1595359535 @default.
- W2059244811 hasRelatedWork W1815857972 @default.
- W2059244811 hasRelatedWork W1968496256 @default.
- W2059244811 hasRelatedWork W1977562050 @default.
- W2059244811 hasRelatedWork W1981418654 @default.
- W2059244811 hasRelatedWork W1981807499 @default.
- W2059244811 hasRelatedWork W1997634402 @default.
- W2059244811 hasRelatedWork W2002466545 @default.
- W2059244811 hasRelatedWork W2026959368 @default.
- W2059244811 hasRelatedWork W2027557194 @default.
- W2059244811 hasRelatedWork W2049123465 @default.
- W2059244811 hasRelatedWork W2056530802 @default.
- W2059244811 hasRelatedWork W2078199626 @default.
- W2059244811 hasRelatedWork W2096278118 @default.
- W2059244811 hasRelatedWork W2140469391 @default.
- W2059244811 hasRelatedWork W2167821242 @default.
- W2059244811 hasRelatedWork W2411870195 @default.
- W2059244811 hasRelatedWork W2426231168 @default.
- W2059244811 hasRelatedWork W252266810 @default.
- W2059244811 hasRelatedWork W271469677 @default.
- W2059244811 isParatext "false" @default.
- W2059244811 isRetracted "false" @default.
- W2059244811 magId "2059244811" @default.
- W2059244811 workType "article" @default.