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- W2059248082 abstract "Seven to eight thousand Pima Indians are presently living in the southwestern desert of Arizona. The prevalence of type II diabetes in this population exceeds 45% and more than 75% of the Pimas are obese. In 1962, Neel proposed that obesity in populations like the Pima Indians might be the expression of a thrifty gene which becomes detrimental with progress. Since 1982, longitudinal studies have been conducted including measurements of metabolic rate in 200 non-diabetic Pima Indians and have shown that 1) at any given body weight and body composition, there is quite a large variability in the resting metabolic rate which is not accounted for by intra-individual variability or errors of the methods; 2) metabolic rate after adjustment for body composition and body weight is a familial trait; 3) a low metabolic rate is a risk factor for body weight gain; 4) in response to body weight gain, there is a normalization of the resting metabolic rate. These studies are the first showing that a thrifty metabolic rate can play a role in the development of obesity." @default.
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- W2059248082 date "1990-01-01" @default.
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- W2059248082 title "Energy Expenditure in the Obese: Is there a Thrifty Gene?" @default.
- W2059248082 doi "https://doi.org/10.1159/000222456" @default.
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