FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059249563> ?p ?o ?g. }

• W2059249563 endingPage "545" @default.
• W2059249563 startingPage "535" @default.
• W2059249563 abstract "Objective To study the pharmacodynamic effects of intravenous temazepam after different infusion rates to pseudo steady-state concentrations. Methods This was a randomized, double-blind, placebo-controlled crossover study in an academic department of clinical pharmacology. Subjects were nine healthy volunteers. A computerized infusion pump was used to obtain target plasma concentrations of temazepam after 30 or 120 minutes and to maintain these levels for 2 hours. A vehicle inftision, similar to the 30-minute (fast) infusion was used as a placebo control. Infusion schedules were based on data obtained from individual subjects after inftision of 0.4 mg/kg temazepam in 30 minutes. Target plasma concentrations were chosen to induce subhypnotic effects and averaged (± SD) 597 ± 123 ng/ml. Venous plasma concentrations of temazepam were measured by HPLC. Free fractions of temazepam were assessed at the start of the pseudo steady-state concentration intervals. Electroencephalogram alpha and beta amplitudes, saccadic peak velocity, and saccadic latency were used as pharmacodynamic parameters. Results The rate of change of plasma concentrations averaged 21 ± 4 ng/ml · min−1 during fast infusion and 5 ± 1 ng/ml · min−1 during slow infusion of temazepam. Average pseudo steady-state concentrations were 639 ± 132 ng/ml after fast infusion and 629 ± 133 ng/ml after slow infusion. At the onset of pseudo steady-state concentration intervals the average free fractions of temazepam were 44% (95% confidence interval, 19% to 61%) lower for slow than for fast infusions. Compared with the slow infusion, electroencephalogram beta amplitudes were significantly larger during the first 30 minutes of pseudo steady-state concentration after fast infusion of temazepam. No significant differences were found for the other parameters. There was a slight decline of temazepam effects during the pseudo steady-state concentration intervals for all parameters after the fast infusion and for saccadic peak velocity and saccadic latency after the slow infusion. Conclusions The pharmacodynamic effects of intravenous temazepam may depend partly on the rate of administration. Differences in pharmacodynamic effects after fast and slow infusions could be caused by changes in protein binding over time. Clinical Pharmacology and Therapeutics (1994) 55, 535–545; doi:10.1038/clpt.1994.67" @default.
• W2059249563 created "2016-06-24" @default.
• W2059249563 creator A5011081386 @default.
• W2059249563 creator A5034417695 @default.
• W2059249563 creator A5047227576 @default.
• W2059249563 creator A5064171630 @default.
• W2059249563 creator A5076466912 @default.
• W2059249563 creator A5077531513 @default.
• W2059249563 creator A5081114214 @default.
• W2059249563 date "1994-05-01" @default.
• W2059249563 modified "2023-09-26" @default.
• W2059249563 title "Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state" @default.
• W2059249563 doi "https://doi.org/10.1038/clpt.1994.67" @default.
• W2059249563 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8181198" @default.
• W2059249563 hasPublicationYear "1994" @default.
• W2059249563 type Work @default.
• W2059249563 sameAs 2059249563 @default.
• W2059249563 citedByCount "12" @default.
• W2059249563 countsByYear W20592495632020 @default.
• W2059249563 crossrefType "journal-article" @default.
• W2059249563 hasAuthorship W2059249563A5011081386 @default.
• W2059249563 hasAuthorship W2059249563A5034417695 @default.
• W2059249563 hasAuthorship W2059249563A5047227576 @default.
• W2059249563 hasAuthorship W2059249563A5064171630 @default.
• W2059249563 hasAuthorship W2059249563A5076466912 @default.
• W2059249563 hasAuthorship W2059249563A5077531513 @default.
• W2059249563 hasAuthorship W2059249563A5081114214 @default.
• W2059249563 hasConcept C11054436 @default.
• W2059249563 hasConcept C112705442 @default.
• W2059249563 hasConcept C118487528 @default.
• W2059249563 hasConcept C126322002 @default.
• W2059249563 hasConcept C142724271 @default.
• W2059249563 hasConcept C147789679 @default.
• W2059249563 hasConcept C153050134 @default.
• W2059249563 hasConcept C170493617 @default.
• W2059249563 hasConcept C185592680 @default.
• W2059249563 hasConcept C204787440 @default.
• W2059249563 hasConcept C27081682 @default.
• W2059249563 hasConcept C2778173252 @default.
• W2059249563 hasConcept C2781006864 @default.
• W2059249563 hasConcept C42219234 @default.
• W2059249563 hasConcept C71924100 @default.
• W2059249563 hasConcept C8171440 @default.
• W2059249563 hasConcept C87813604 @default.
• W2059249563 hasConcept C98274493 @default.
• W2059249563 hasConceptScore W2059249563C11054436 @default.
• W2059249563 hasConceptScore W2059249563C112705442 @default.
• W2059249563 hasConceptScore W2059249563C118487528 @default.
• W2059249563 hasConceptScore W2059249563C126322002 @default.
• W2059249563 hasConceptScore W2059249563C142724271 @default.
• W2059249563 hasConceptScore W2059249563C147789679 @default.
• W2059249563 hasConceptScore W2059249563C153050134 @default.
• W2059249563 hasConceptScore W2059249563C170493617 @default.
• W2059249563 hasConceptScore W2059249563C185592680 @default.
• W2059249563 hasConceptScore W2059249563C204787440 @default.
• W2059249563 hasConceptScore W2059249563C27081682 @default.
• W2059249563 hasConceptScore W2059249563C2778173252 @default.
• W2059249563 hasConceptScore W2059249563C2781006864 @default.
• W2059249563 hasConceptScore W2059249563C42219234 @default.
• W2059249563 hasConceptScore W2059249563C71924100 @default.
• W2059249563 hasConceptScore W2059249563C8171440 @default.
• W2059249563 hasConceptScore W2059249563C87813604 @default.
• W2059249563 hasConceptScore W2059249563C98274493 @default.
• W2059249563 hasIssue "5" @default.
• W2059249563 hasLocation W20592495631 @default.
• W2059249563 hasLocation W20592495632 @default.
• W2059249563 hasOpenAccess W2059249563 @default.
• W2059249563 hasPrimaryLocation W20592495631 @default.
• W2059249563 hasRelatedWork W1554177699 @default.
• W2059249563 hasRelatedWork W1987341925 @default.
• W2059249563 hasRelatedWork W2059249563 @default.
• W2059249563 hasRelatedWork W2066380109 @default.
• W2059249563 hasRelatedWork W2114559484 @default.
• W2059249563 hasRelatedWork W2118744752 @default.
• W2059249563 hasRelatedWork W2395362711 @default.
• W2059249563 hasRelatedWork W2422610488 @default.
• W2059249563 hasRelatedWork W2748952813 @default.
• W2059249563 hasRelatedWork W2899084033 @default.
• W2059249563 hasVolume "55" @default.
• W2059249563 isParatext "false" @default.
• W2059249563 isRetracted "false" @default.
• W2059249563 magId "2059249563" @default.
• W2059249563 workType "article" @default.