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- W2059254078 abstract "Digestion of chromatin with micrococcal nuclease under mild conditions results in the release of a minor chromatin fraction showing an increased RNA and non-histone protein content, a fast turnover of the non-histone proteins and the presence of rapidly labelled heterogeneous nuclear RNA (hnRNA) with half-life of about 20 min. Further digestion of the chromatin leads to the elimination of about 19% of the initial chromosomal DNA, thus leaving a second chromatin fraction relatively resistant to nuclease attack. This fraction has a low protein and RNA content and contains only metabolically stable non-histone proteins. No differences in the histone complement of the two fractions was found except for a 40% deficiency of H1 in the minor fraction." @default.
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- W2059254078 date "1979-06-01" @default.
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- W2059254078 title "Two Chromatin Fractions with Different Metabolic Properties of Non-histone Proteins and of Newly Synthesized RNA" @default.
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- W2059254078 doi "https://doi.org/10.1111/j.1432-1033.1979.tb13094.x" @default.
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