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- W2059263124 abstract "Abstract Host-restricted ( hr ) mutants of vesicular stomatitis virus were previously isolated and found to be defective for virus-specific RNA synthesis based on impaired uptake of RNA precursors by nonpermissive human cells [ Simpson, R. W., and Obijeski, J. F. (1974). Virology 57 , 357–368. ]. This study has allowed a further classification of some of these mutants according to the RNA species detected by electrophoretic analysis of total cytoplasmic RNA extracted from infected, actinomycin-treated cells. In HeLa/M cells, the mutants examined produced either no detectable RNA or all expected size classes (12–18 S, 30 S, 42 S). However, the former type of mutant could be shown to initiate primary transcription in vivo . HeLa/Ohio cells were found to be substantially more permissive than HeLa/M or other human cells for growth of most hr mutants tested. The patterns of RNA synthesis observed with different hr mutants in HeLa/Ohio cells included no detectable species, deficiencies for 42 S RNA, or production of all expected size classes. As a biochemical correlate of complementation, enhanced RNA synthesis and viral replication could be demonstrated in HeLa/Ohio cells doubly infected with certain pairs of hr mutants. These data illustrate that the intracellular synthesis of virus-specific RNA species by VSV is controlled, in part, by cellular factors which are yet to be identified." @default.
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- W2059263124 date "1979-03-01" @default.
- W2059263124 modified "2023-09-26" @default.
- W2059263124 title "Conditional lethal mutants of vesicular stomatitis virus IV. RNA species detected in nonpermissive cells infected with host-restricted mutants" @default.
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- W2059263124 doi "https://doi.org/10.1016/0042-6822(79)90253-8" @default.
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