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- W2059269705 abstract "This study evaluated and compared the potential protective effects of probucol and succinobucol, two lipid-lowering compounds with anti-inflammatory and antioxidant properties, on oxidative stress and mitochondrial dysfunction induced by 3-nitropropionic acid (3-NP, a succinate dehydrogenase (SDH) inhibitor largely used as model of Huntington's disease) in rat brain mitochondria-enriched synaptosomes. 3-NP caused significant inhibition of mitochondrial complex II activity, induced mitochondrial dysfunction and oxidative stress. Probucol and succinobucol prevented oxidative stress, but only succinobucol was able to prevent the mitochondrial dysfunction induced by 3-NP. Succinobucol, which did not recover complex II inhibition, was able to protect against 3-NP-induced decreased of MTT reduction, indicating that SDH is not the only enzyme responsible for MTT reduction. The present findings suggest that succinobucol might be a novel strategy to slow or halt oxidative events in neurodegenerative conditions." @default.
- W2059269705 created "2016-06-24" @default.
- W2059269705 creator A5021410248 @default.
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- W2059269705 creator A5051024171 @default.
- W2059269705 creator A5051428255 @default.
- W2059269705 creator A5052077381 @default.
- W2059269705 creator A5068024387 @default.
- W2059269705 date "2013-03-01" @default.
- W2059269705 modified "2023-09-27" @default.
- W2059269705 title "Succinobucol versus probucol: Higher efficiency of succinobucol in mitigating 3-NP-induced brain mitochondrial dysfunction and oxidative stress in vitro" @default.
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- W2059269705 doi "https://doi.org/10.1016/j.mito.2013.01.005" @default.
- W2059269705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23333792" @default.
- W2059269705 hasPublicationYear "2013" @default.
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