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• W2059272239 abstract "Sodium nitrite was added to suspensions of washed guinea pig red cells in concentrations which converted about a third of the total blood pigment to methemoglobin. Various aliquots also contained added ascorbic acid in concentrations of 0.05, 0.5, or 5.0 mm (“physiological” levels are between 0.05 and 0.1 mm). Methemoglobin levels were followed for 2 hr at 37°C. None of the tested concentrations of ascorbate significantly attenuated methemoglobin formation. On the contrary, significantly higher methemoglobin levels were sometimes found with 5.0 mm ascorbate. Guinea pigs were maintained several weeks on a scorbutogenic diet with or without ascorbate supplementation in their water. When blood ascorbate levels were significantly different, both groups were given intraarterial sodium nitrite, 40 mg/kg, and methemoglobin levels were followed with time as above. At none of the sampling times was there a significant difference in the methemoglobin levels between the 2 groups. As judged by the appearance of radioactivity in blood at various times after sc injection, the two groups also showed no difference in the rates at which they absorbed KS14CN. In human red cell suspensions 5.0 mm ascorbate significantly attenuated the methemoglobinemic response to tested concentrations of sodium nitrite, hydroxylamine and phenylhydroxylamine at 1 hr, but lower concentrations of ascorbate were without effect. When human red cells were first exposed to nitrite, then washed and ascorbate added, significant acceleration of methemoglobin reduction was observed with 5.0 mm ascorbate at 12, 24, and 36 hr, and with 0.5 mm ascorbate at 12 and 24 hr. In contrast, the oxygen capacities of suspensions with 5.0 mm ascorbate were significantly higher than control only at 12 and 24 hr, whereas with 0.5 mm ascorbate they were significantly higher at 12, 24, and 36 hr. In plain buffer, 5.0 mm ascorbate produced a small but significant loss of the tested concentration of sodium nitrite within 2 hr, but not at shorter intervals or at lower ascorbate concentrations." @default.
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• W2059272239 date "1972-02-01" @default.
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• W2059272239 title "Ascorbic acid and chemically induced methemoglobinemias" @default.
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• W2059272239 doi "https://doi.org/10.1016/0041-008x(72)90060-9" @default.
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