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• W2059274166 abstract "The factors responsible for the phenotypic heterogeneity of memory CD4 T cells are unclear. In the present study, we have identified a third population of memory CD4 T cells characterized as CD45RA+CCR7– that, based on its replication history and the homeostatic proliferative capacity, was at an advanced stage of differentiation. Three different phenotypic patterns of memory CD4 T cell responses were delineated under different conditions of antigen (Ag) persistence and load using CD45RA and CCR7 as markers of memory T cells. Mono-phenotypic CD45RA–CCR7+ or CD45RA–CCR7– CD4 T cell responses were associated with conditions of Ag clearance (tetanus toxoid-specific CD4 T cell response) or Ag persistence and high load (chronic HIV-1 and primary CMV infections), respectively. Multi-phenotypic CD45RA–CCR7+, CD45RA–CCR7– and CD45RA+CCR7– CD4 T cell responses were associated with protracted Ag exposure and low load (chronic CMV, EBV and HSV infections and HIV-1 infection in long-term nonprogressors). The mono-phenotypic CD45RA–CCR7+ response was typical of central memory (TCM) IL-2-secreting CD4 T cells, the mono-phenotypic CD45RA–CCR7– response of effector memory (TEM) IFN-γ-secreting CD4 T cells and the multi-phenotypic response of both IL-2- and IFN-γ-secreting cells. The present results indicate that the heterogeneity of different Ag-specific CD4 T cell responses is regulated by Ag exposure and Ag load." @default.
• W2059274166 created "2016-06-24" @default.
• W2059274166 creator A5007165900 @default.
• W2059274166 creator A5035745685 @default.
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• W2059274166 date "2004-12-01" @default.
• W2059274166 modified "2023-10-17" @default.
• W2059274166 title "Phenotypic heterogeneity of antigen-specific CD4 T cells under different conditions of antigen persistence and antigen load" @default.
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• W2059274166 doi "https://doi.org/10.1002/eji.200425324" @default.
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