FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059278695> ?p ?o ?g. }

• W2059278695 endingPage "505" @default.
• W2059278695 startingPage "495" @default.
• W2059278695 abstract "The primary objective of this study was to identify and clone the first nonmammalian thrombopoietin (TPO), chicken TPO, and its receptor c-Mpl for the purpose of characterizing their activities both in vitro and in vivo.Chicken TPO was cloned using the methods of reverse transcriptase polymerase chain reaction and rapid amplification of cDNA ends. Northern blotting and RNAse protection assays were employed to analyze the levels of RNA expression in a panel of tissues and cell lines. To study cell surface expression of c-Mpl, polyclonal antibodies were prepared against bacterially derived c-Mpl. Both baculovirus-derived recombinant TPO and retrovirally expressed TPO and c-Mpl were used for the in vivo experiments.Both chicken TPO and its receptor c-Mpl were identified and cloned. Expression of chicken TPO was restricted to only the liver and spleen, while c-mpl was expressed in the bone marrow, lung, and spleen. In vitro experiments with sorted multipotent chicken bone marrow-derived progenitors demonstrated that TPO plays a role in the commitment of these cells to the thrombocytic lineage. Furthermore, TPO in cooperation with stem cell factor also supports proliferation of multipotent progenitors. In experimental animals, the intravenous application of recombinant chicken TPO or overexpression of TPO and c-mpl via retroviral infection lead to erythroblastosis and thromboblastosis.The characterized chicken thrombopoietin and its receptor c-Mpl will be valuable tools to further study thrombocytic differentiation and hematopoietic stem cell development. Moreover, the introduced experimental model of the chicken bipotent thrombo-/erythropoietic-progenitor can be used to identify key regulators of cell fate determination." @default.
• W2059278695 created "2016-06-24" @default.
• W2059278695 creator A5004290451 @default.
• W2059278695 creator A5009238334 @default.
• W2059278695 creator A5033517685 @default.
• W2059278695 creator A5048252414 @default.
• W2059278695 creator A5051877079 @default.
• W2059278695 creator A5059421008 @default.
• W2059278695 creator A5072745148 @default.
• W2059278695 creator A5084970131 @default.
• W2059278695 date "2008-04-01" @default.
• W2059278695 modified "2023-09-30" @default.
• W2059278695 title "Impact of chicken thrombopoietin and its receptor c-Mpl on hematopoietic cell development" @default.
• W2059278695 cites W1455039869 @default.
• W2059278695 cites W1501494607 @default.
• W2059278695 cites W193519295 @default.
• W2059278695 cites W1965375035 @default.
• W2059278695 cites W1966704271 @default.
• W2059278695 cites W1970888804 @default.
• W2059278695 cites W1972561843 @default.
• W2059278695 cites W1974136591 @default.
• W2059278695 cites W1978040187 @default.
• W2059278695 cites W1978573420 @default.
• W2059278695 cites W1980727748 @default.
• W2059278695 cites W1982130774 @default.
• W2059278695 cites W1983612778 @default.
• W2059278695 cites W1984270581 @default.
• W2059278695 cites W1995172129 @default.
• W2059278695 cites W1996683133 @default.
• W2059278695 cites W1997632886 @default.
• W2059278695 cites W2011177354 @default.
• W2059278695 cites W2011712697 @default.
• W2059278695 cites W2017955228 @default.
• W2059278695 cites W2019840092 @default.
• W2059278695 cites W2022838565 @default.
• W2059278695 cites W2025589527 @default.
• W2059278695 cites W2029919655 @default.
• W2059278695 cites W2035673746 @default.
• W2059278695 cites W2048502745 @default.
• W2059278695 cites W2050666722 @default.
• W2059278695 cites W2061837158 @default.
• W2059278695 cites W2062853747 @default.
• W2059278695 cites W2064443141 @default.
• W2059278695 cites W2067181610 @default.
• W2059278695 cites W2078038866 @default.
• W2059278695 cites W2082873874 @default.
• W2059278695 cites W2085393172 @default.
• W2059278695 cites W2086997710 @default.
• W2059278695 cites W2088583545 @default.
• W2059278695 cites W2089468267 @default.
• W2059278695 cites W2090786449 @default.
• W2059278695 cites W2093758335 @default.
• W2059278695 cites W2097368877 @default.
• W2059278695 cites W2097416336 @default.
• W2059278695 cites W2105651368 @default.
• W2059278695 cites W2125090287 @default.
• W2059278695 cites W2128964789 @default.
• W2059278695 cites W2143531841 @default.
• W2059278695 cites W2146504406 @default.
• W2059278695 cites W2150650800 @default.
• W2059278695 cites W2153503145 @default.
• W2059278695 cites W2168986361 @default.
• W2059278695 cites W2171419477 @default.
• W2059278695 cites W2221685362 @default.
• W2059278695 cites W2230842386 @default.
• W2059278695 cites W2256952023 @default.
• W2059278695 cites W2263191133 @default.
• W2059278695 cites W2335346156 @default.
• W2059278695 cites W2344941588 @default.
• W2059278695 cites W236835068 @default.
• W2059278695 cites W4210580032 @default.
• W2059278695 cites W4236231326 @default.
• W2059278695 cites W4236329840 @default.
• W2059278695 cites W4237093511 @default.
• W2059278695 cites W4239733177 @default.
• W2059278695 cites W869346529 @default.
• W2059278695 doi "https://doi.org/10.1016/j.exphem.2007.12.001" @default.
• W2059278695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18243490" @default.
• W2059278695 hasPublicationYear "2008" @default.
• W2059278695 type Work @default.
• W2059278695 sameAs 2059278695 @default.
• W2059278695 citedByCount "17" @default.
• W2059278695 countsByYear W20592786952012 @default.
• W2059278695 countsByYear W20592786952014 @default.
• W2059278695 countsByYear W20592786952015 @default.
• W2059278695 countsByYear W20592786952016 @default.
• W2059278695 countsByYear W20592786952018 @default.
• W2059278695 countsByYear W20592786952020 @default.
• W2059278695 countsByYear W20592786952022 @default.
• W2059278695 crossrefType "journal-article" @default.
• W2059278695 hasAuthorship W2059278695A5004290451 @default.
• W2059278695 hasAuthorship W2059278695A5009238334 @default.
• W2059278695 hasAuthorship W2059278695A5033517685 @default.
• W2059278695 hasAuthorship W2059278695A5048252414 @default.
• W2059278695 hasAuthorship W2059278695A5051877079 @default.
• W2059278695 hasAuthorship W2059278695A5059421008 @default.
• W2059278695 hasAuthorship W2059278695A5072745148 @default.
• W2059278695 hasAuthorship W2059278695A5084970131 @default.

• next