FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059283396> ?p ?o ?g. }

• W2059283396 endingPage "214" @default.
• W2059283396 startingPage "208" @default.
• W2059283396 abstract "Background The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD). Objective The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround inhibition, which is deficient in FHD. Methods Single- and paired-pulse transcranial magnetic stimulation (TMS) was applied during different phases of an index finger movement using the abductor pollicis brevis muscle (APB), a surrounding, nonsynergistic muscle, as target muscle. To look at the effect of PMd on the primary motor cortex (M1), a subthreshold conditioning pulse was applied to PMd 6 milliseconds before stimulation over M1. Results There was surround inhibition during movement initiation in controls, but not in FHD patients. In contrast, FHD patients, but not controls, showed premotor-motor inhibition (PMI) at rest. During movement, PMI was absent in both groups. Conclusions We conclude that PMI does not appear to play a key role in the formation of surround inhibition in normal subjects, because it was not enhanced during movement initiation. However, in FHD, inhibition from PMd on M1 was abnormally increased at rest and declined during movement initiation. The behavior of PMd can therefore partly explain the loss of surround inhibition in the FHD patients. The functional significance of increased PMI at rest is not clear, but might be an attempt of compensation for losses of inhibition from other brain areas. The left dorsal premotor cortex (PMd) plays an important role in movement selection and is abnormally activated in imaging studies in patients with right-sided focal hand dystonia (FHD). The aims of this study were to assess the role of left PMd in patients with FHD and in the genesis of surround inhibition, which is deficient in FHD. Single- and paired-pulse transcranial magnetic stimulation (TMS) was applied during different phases of an index finger movement using the abductor pollicis brevis muscle (APB), a surrounding, nonsynergistic muscle, as target muscle. To look at the effect of PMd on the primary motor cortex (M1), a subthreshold conditioning pulse was applied to PMd 6 milliseconds before stimulation over M1. There was surround inhibition during movement initiation in controls, but not in FHD patients. In contrast, FHD patients, but not controls, showed premotor-motor inhibition (PMI) at rest. During movement, PMI was absent in both groups. We conclude that PMI does not appear to play a key role in the formation of surround inhibition in normal subjects, because it was not enhanced during movement initiation. However, in FHD, inhibition from PMd on M1 was abnormally increased at rest and declined during movement initiation. The behavior of PMd can therefore partly explain the loss of surround inhibition in the FHD patients. The functional significance of increased PMI at rest is not clear, but might be an attempt of compensation for losses of inhibition from other brain areas." @default.
• W2059283396 created "2016-06-24" @default.
• W2059283396 creator A5001366785 @default.
• W2059283396 creator A5005566965 @default.
• W2059283396 creator A5069321383 @default.
• W2059283396 creator A5083360095 @default.
• W2059283396 date "2009-10-01" @default.
• W2059283396 modified "2023-10-16" @default.
• W2059283396 title "The role of inhibition from the left dorsal premotor cortex in right-sided focal hand dystonia" @default.
• W2059283396 cites W1657449297 @default.
• W2059283396 cites W1965762009 @default.
• W2059283396 cites W1968429176 @default.
• W2059283396 cites W1968565302 @default.
• W2059283396 cites W1981720523 @default.
• W2059283396 cites W1989849034 @default.
• W2059283396 cites W1992762512 @default.
• W2059283396 cites W1999656205 @default.
• W2059283396 cites W2011595516 @default.
• W2059283396 cites W2012652415 @default.
• W2059283396 cites W2024933671 @default.
• W2059283396 cites W2037475508 @default.
• W2059283396 cites W2050751924 @default.
• W2059283396 cites W2060870333 @default.
• W2059283396 cites W2066439376 @default.
• W2059283396 cites W2083702277 @default.
• W2059283396 cites W2086623779 @default.
• W2059283396 cites W2092634513 @default.
• W2059283396 cites W2093694779 @default.
• W2059283396 cites W2101833134 @default.
• W2059283396 cites W2104134096 @default.
• W2059283396 cites W2118225192 @default.
• W2059283396 cites W2130099774 @default.
• W2059283396 cites W2131802648 @default.
• W2059283396 cites W2134659016 @default.
• W2059283396 cites W2136022845 @default.
• W2059283396 cites W2150016564 @default.
• W2059283396 cites W2168636536 @default.
• W2059283396 cites W2169875337 @default.
• W2059283396 doi "https://doi.org/10.1016/j.brs.2009.03.004" @default.
• W2059283396 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3787900" @default.
• W2059283396 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20633420" @default.
• W2059283396 hasPublicationYear "2009" @default.
• W2059283396 type Work @default.
• W2059283396 sameAs 2059283396 @default.
• W2059283396 citedByCount "38" @default.
• W2059283396 countsByYear W20592833962012 @default.
• W2059283396 countsByYear W20592833962013 @default.
• W2059283396 countsByYear W20592833962014 @default.
• W2059283396 countsByYear W20592833962015 @default.
• W2059283396 countsByYear W20592833962016 @default.
• W2059283396 countsByYear W20592833962018 @default.
• W2059283396 countsByYear W20592833962019 @default.
• W2059283396 countsByYear W20592833962020 @default.
• W2059283396 countsByYear W20592833962023 @default.
• W2059283396 crossrefType "journal-article" @default.
• W2059283396 hasAuthorship W2059283396A5001366785 @default.
• W2059283396 hasAuthorship W2059283396A5005566965 @default.
• W2059283396 hasAuthorship W2059283396A5069321383 @default.
• W2059283396 hasAuthorship W2059283396A5083360095 @default.
• W2059283396 hasBestOaLocation W20592833962 @default.
• W2059283396 hasConcept C105702510 @default.
• W2059283396 hasConcept C140530291 @default.
• W2059283396 hasConcept C15744967 @default.
• W2059283396 hasConcept C169760540 @default.
• W2059283396 hasConcept C24998067 @default.
• W2059283396 hasConcept C2777348757 @default.
• W2059283396 hasConcept C2778373776 @default.
• W2059283396 hasConcept C2778559928 @default.
• W2059283396 hasConcept C2778581513 @default.
• W2059283396 hasConcept C2779534489 @default.
• W2059283396 hasConcept C2780307956 @default.
• W2059283396 hasConcept C71924100 @default.
• W2059283396 hasConceptScore W2059283396C105702510 @default.
• W2059283396 hasConceptScore W2059283396C140530291 @default.
• W2059283396 hasConceptScore W2059283396C15744967 @default.
• W2059283396 hasConceptScore W2059283396C169760540 @default.
• W2059283396 hasConceptScore W2059283396C24998067 @default.
• W2059283396 hasConceptScore W2059283396C2777348757 @default.
• W2059283396 hasConceptScore W2059283396C2778373776 @default.
• W2059283396 hasConceptScore W2059283396C2778559928 @default.
• W2059283396 hasConceptScore W2059283396C2778581513 @default.
• W2059283396 hasConceptScore W2059283396C2779534489 @default.
• W2059283396 hasConceptScore W2059283396C2780307956 @default.
• W2059283396 hasConceptScore W2059283396C71924100 @default.
• W2059283396 hasIssue "4" @default.
• W2059283396 hasLocation W20592833961 @default.
• W2059283396 hasLocation W20592833962 @default.
• W2059283396 hasLocation W20592833963 @default.
• W2059283396 hasLocation W20592833964 @default.
• W2059283396 hasOpenAccess W2059283396 @default.
• W2059283396 hasPrimaryLocation W20592833961 @default.
• W2059283396 hasRelatedWork W1657449297 @default.
• W2059283396 hasRelatedWork W1961049053 @default.
• W2059283396 hasRelatedWork W1997730257 @default.
• W2059283396 hasRelatedWork W2027595995 @default.
• W2059283396 hasRelatedWork W2085357995 @default.
• W2059283396 hasRelatedWork W2085368083 @default.
• W2059283396 hasRelatedWork W2118349676 @default.

• next