FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059283408> ?p ?o ?g. }

• W2059283408 endingPage "270" @default.
• W2059283408 startingPage "266" @default.
• W2059283408 abstract "This study deals with the biodistribution of syngeneic radiolabeled lymphokine-activated killer (LAK) cells in Wag rats after infusion via the hepatic artery or the jugular vein. The biodistribution of IIIIndium-labeled LAK cells was evaluated using serial whole-body gamma camera imaging. Furthermore, we investigated 2 factors that might influence the biodistribution of these effector cells: purity of LAK cells and administration of interleukin-2 (IL-2). After injection of IIIIndium-labeled LAK cells via the hepatic artery or via the jugular vein we could detect important differences in the biodistribution pattern up to 5 hr after injection. LAK cells administered via the jugular vein were all found in the lungs up to 2 hr after injection and then redistributed to the liver and to the spleen. LAK cells administered via the hepatic artery were all found in the liver after injection and redistributed after 2 hr mainly to the spleen. About 8 hr after injection we could no longer detect any differences in the biodistribution pattern according to the route of administration. Biodistribution was followed for up to 72 hr after injection but the pattern showed no change after 8 hr, whichever the route of administration. A purified adherent-LAK population, a large granular lymphocyte culture with only 6% T cells, showed the same distribution pattern as standard LAK cells (40% T cells). Infusion of 40,000 units of IL-2 per day, starting 3 days before and continuing after administration of radio-labeled LAK cells, accelerated the redistribution of these cells by both routes of administration. We conclude that up to 2 hr after local infusion, a high concentration of LAK cells in the first capillary bed can be obtained. Therefore, local administration of LAK cells may be more effective against tumors. © 1992 Wiley-Liss, Inc." @default.
• W2059283408 created "2016-06-24" @default.
• W2059283408 creator A5022410579 @default.
• W2059283408 creator A5046601842 @default.
• W2059283408 creator A5050518452 @default.
• W2059283408 creator A5052579165 @default.
• W2059283408 creator A5058922925 @default.
• W2059283408 creator A5059875035 @default.
• W2059283408 creator A5068540938 @default.
• W2059283408 date "1992-09-09" @default.
• W2059283408 modified "2023-10-17" @default.
• W2059283408 title "Biodistribution of lymphokine-activated killer (LAK) cells in WAG rats after hepatic-artery or jugular-vein infusion" @default.
• W2059283408 cites W1975568557 @default.
• W2059283408 cites W1980483077 @default.
• W2059283408 cites W1983299898 @default.
• W2059283408 cites W1986656701 @default.
• W2059283408 cites W1991136079 @default.
• W2059283408 cites W2005294508 @default.
• W2059283408 cites W2014113952 @default.
• W2059283408 cites W2022101147 @default.
• W2059283408 cites W2036886029 @default.
• W2059283408 cites W2062994527 @default.
• W2059283408 cites W2068391435 @default.
• W2059283408 cites W2070684861 @default.
• W2059283408 cites W2104735980 @default.
• W2059283408 cites W2104999155 @default.
• W2059283408 cites W2144654542 @default.
• W2059283408 doi "https://doi.org/10.1002/ijc.2910520219" @default.
• W2059283408 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1521913" @default.
• W2059283408 hasPublicationYear "1992" @default.
• W2059283408 type Work @default.
• W2059283408 sameAs 2059283408 @default.
• W2059283408 citedByCount "22" @default.
• W2059283408 countsByYear W20592834082012 @default.
• W2059283408 countsByYear W20592834082013 @default.
• W2059283408 countsByYear W20592834082022 @default.
• W2059283408 crossrefType "journal-article" @default.
• W2059283408 hasAuthorship W2059283408A5022410579 @default.
• W2059283408 hasAuthorship W2059283408A5046601842 @default.
• W2059283408 hasAuthorship W2059283408A5050518452 @default.
• W2059283408 hasAuthorship W2059283408A5052579165 @default.
• W2059283408 hasAuthorship W2059283408A5058922925 @default.
• W2059283408 hasAuthorship W2059283408A5059875035 @default.
• W2059283408 hasAuthorship W2059283408A5068540938 @default.
• W2059283408 hasConcept C126322002 @default.
• W2059283408 hasConcept C129374314 @default.
• W2059283408 hasConcept C142724271 @default.
• W2059283408 hasConcept C185592680 @default.
• W2059283408 hasConcept C202751555 @default.
• W2059283408 hasConcept C203014093 @default.
• W2059283408 hasConcept C2776090121 @default.
• W2059283408 hasConcept C2777371288 @default.
• W2059283408 hasConcept C2777761686 @default.
• W2059283408 hasConcept C2777807558 @default.
• W2059283408 hasConcept C2777956836 @default.
• W2059283408 hasConcept C2780931953 @default.
• W2059283408 hasConcept C28651165 @default.
• W2059283408 hasConcept C49382859 @default.
• W2059283408 hasConcept C55493867 @default.
• W2059283408 hasConcept C71924100 @default.
• W2059283408 hasConcept C8891405 @default.
• W2059283408 hasConcept C98274493 @default.
• W2059283408 hasConceptScore W2059283408C126322002 @default.
• W2059283408 hasConceptScore W2059283408C129374314 @default.
• W2059283408 hasConceptScore W2059283408C142724271 @default.
• W2059283408 hasConceptScore W2059283408C185592680 @default.
• W2059283408 hasConceptScore W2059283408C202751555 @default.
• W2059283408 hasConceptScore W2059283408C203014093 @default.
• W2059283408 hasConceptScore W2059283408C2776090121 @default.
• W2059283408 hasConceptScore W2059283408C2777371288 @default.
• W2059283408 hasConceptScore W2059283408C2777761686 @default.
• W2059283408 hasConceptScore W2059283408C2777807558 @default.
• W2059283408 hasConceptScore W2059283408C2777956836 @default.
• W2059283408 hasConceptScore W2059283408C2780931953 @default.
• W2059283408 hasConceptScore W2059283408C28651165 @default.
• W2059283408 hasConceptScore W2059283408C49382859 @default.
• W2059283408 hasConceptScore W2059283408C55493867 @default.
• W2059283408 hasConceptScore W2059283408C71924100 @default.
• W2059283408 hasConceptScore W2059283408C8891405 @default.
• W2059283408 hasConceptScore W2059283408C98274493 @default.
• W2059283408 hasIssue "2" @default.
• W2059283408 hasLocation W20592834081 @default.
• W2059283408 hasLocation W20592834082 @default.
• W2059283408 hasOpenAccess W2059283408 @default.
• W2059283408 hasPrimaryLocation W20592834081 @default.
• W2059283408 hasRelatedWork W1535065630 @default.
• W2059283408 hasRelatedWork W1967360579 @default.
• W2059283408 hasRelatedWork W1978551452 @default.
• W2059283408 hasRelatedWork W2064195300 @default.
• W2059283408 hasRelatedWork W2065367149 @default.
• W2059283408 hasRelatedWork W2096574716 @default.
• W2059283408 hasRelatedWork W2133759650 @default.
• W2059283408 hasRelatedWork W2417793608 @default.
• W2059283408 hasRelatedWork W2616137125 @default.
• W2059283408 hasRelatedWork W4290241734 @default.
• W2059283408 hasVolume "52" @default.
• W2059283408 isParatext "false" @default.
• W2059283408 isRetracted "false" @default.

• next