FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059289119> ?p ?o ?g. }

• W2059289119 endingPage "e5153" @default.
• W2059289119 startingPage "e5153" @default.
• W2059289119 abstract "Estradiol may fulfill a plethora of functions in neurons, in which much of its activity is associated with its capacity to directly bind and dimerize estrogen receptors. This hormone-protein complex can either bind directly to estrogen response elements (ERE's) in gene promoters, or it may act as a cofactor at non-ERE sites interacting with other DNA-binding elements such as AP-1 or c-Jun. Many of the neuroprotective effects described for estrogen have been associated with this mode of action. However, recent evidence suggests that in addition to these genomic effects, estrogen may also act as a more general trophic factor triggering cytoplasmic signals and extending the potential activity of this hormone. We demonstrated that estrogen receptor alpha associates with beta-catenin and glycogen synthase kinase 3 in the brain and in neurons, which has since been confirmed by others. Here, we show that the action of estradiol activates beta-catenin transcription in neuroblastoma cells and in primary cortical neurons. This activation is time and concentration-dependent, and it may be abolished by the estrogen receptor antagonist ICI 182780. The transcriptional activation of beta-catenin is dependent on lymphoid enhancer binding factor-1 (LEF-1) and a truncated-mutant of LEF-1 almost completely blocks estradiol TCF-mediated transcription. Transcription of a TCF-reporter in a transgenic mouse model is enhanced by estradiol in a similar fashion to that produced by Wnt3a. In addition, activation of a luciferase reporter driven by the engrailed promoter with three LEF-1 repeats was mediated by estradiol. We established a cell line that constitutively expresses a dominant-negative LEF-1 and it was used in a gene expression microarray analysis. In this way, genes that respond to estradiol or Wnt3a, sensitive to LEF-1, could be identified and validated. Together, these data demonstrate the existence of a new signaling pathway controlled by estradiol in neurons. This pathway shares some elements of the insulin-like growth factor-1/Insulin and Wnt signaling pathways, however, our data strongly suggest that it is different from that of both these ligands. These findings may reveal a set of new physiological roles for estrogens, at least in the Central Nervous System (CNS)." @default.
• W2059289119 created "2016-06-24" @default.
• W2059289119 creator A5025650833 @default.
• W2059289119 creator A5031347216 @default.
• W2059289119 creator A5036293904 @default.
• W2059289119 creator A5068585849 @default.
• W2059289119 creator A5084027100 @default.
• W2059289119 creator A5087874511 @default.
• W2059289119 date "2009-04-10" @default.
• W2059289119 modified "2023-10-18" @default.
• W2059289119 title "Estradiol Activates β-Catenin Dependent Transcription in Neurons" @default.
• W2059289119 cites W1554815317 @default.
• W2059289119 cites W1586125594 @default.
• W2059289119 cites W1771495220 @default.
• W2059289119 cites W1809411463 @default.
• W2059289119 cites W1918726675 @default.
• W2059289119 cites W1967803088 @default.
• W2059289119 cites W1968507832 @default.
• W2059289119 cites W1971960644 @default.
• W2059289119 cites W1979512659 @default.
• W2059289119 cites W1981766282 @default.
• W2059289119 cites W1987183940 @default.
• W2059289119 cites W1994320218 @default.
• W2059289119 cites W1994526084 @default.
• W2059289119 cites W1995192985 @default.
• W2059289119 cites W2001992345 @default.
• W2059289119 cites W2002190647 @default.
• W2059289119 cites W2007819180 @default.
• W2059289119 cites W2013831911 @default.
• W2059289119 cites W2025595769 @default.
• W2059289119 cites W2025923976 @default.
• W2059289119 cites W2026463041 @default.
• W2059289119 cites W2033420737 @default.
• W2059289119 cites W2037148314 @default.
• W2059289119 cites W2038087401 @default.
• W2059289119 cites W2045671770 @default.
• W2059289119 cites W2047801596 @default.
• W2059289119 cites W2053265248 @default.
• W2059289119 cites W2054080205 @default.
• W2059289119 cites W2058269906 @default.
• W2059289119 cites W2064890294 @default.
• W2059289119 cites W2069551285 @default.
• W2059289119 cites W2071716550 @default.
• W2059289119 cites W2073353512 @default.
• W2059289119 cites W2080719784 @default.
• W2059289119 cites W2080842591 @default.
• W2059289119 cites W2089068494 @default.
• W2059289119 cites W2093758184 @default.
• W2059289119 cites W2095197305 @default.
• W2059289119 cites W2100481402 @default.
• W2059289119 cites W2102042818 @default.
• W2059289119 cites W2107106369 @default.
• W2059289119 cites W2109069210 @default.
• W2059289119 cites W2112183341 @default.
• W2059289119 cites W2114358785 @default.
• W2059289119 cites W2117100349 @default.
• W2059289119 cites W2119504151 @default.
• W2059289119 cites W2130933380 @default.
• W2059289119 cites W2141175150 @default.
• W2059289119 cites W2143418242 @default.
• W2059289119 cites W2143481850 @default.
• W2059289119 cites W2149875309 @default.
• W2059289119 cites W2154473845 @default.
• W2059289119 cites W2162572073 @default.
• W2059289119 cites W2169457085 @default.
• W2059289119 cites W2327662101 @default.
• W2059289119 doi "https://doi.org/10.1371/journal.pone.0005153" @default.
• W2059289119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2664482" @default.
• W2059289119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19360103" @default.
• W2059289119 hasPublicationYear "2009" @default.
• W2059289119 type Work @default.
• W2059289119 sameAs 2059289119 @default.
• W2059289119 citedByCount "70" @default.
• W2059289119 countsByYear W20592891192012 @default.
• W2059289119 countsByYear W20592891192013 @default.
• W2059289119 countsByYear W20592891192014 @default.
• W2059289119 countsByYear W20592891192015 @default.
• W2059289119 countsByYear W20592891192016 @default.
• W2059289119 countsByYear W20592891192017 @default.
• W2059289119 countsByYear W20592891192018 @default.
• W2059289119 countsByYear W20592891192019 @default.
• W2059289119 countsByYear W20592891192020 @default.
• W2059289119 countsByYear W20592891192021 @default.
• W2059289119 countsByYear W20592891192022 @default.
• W2059289119 countsByYear W20592891192023 @default.
• W2059289119 crossrefType "journal-article" @default.
• W2059289119 hasAuthorship W2059289119A5025650833 @default.
• W2059289119 hasAuthorship W2059289119A5031347216 @default.
• W2059289119 hasAuthorship W2059289119A5036293904 @default.
• W2059289119 hasAuthorship W2059289119A5068585849 @default.
• W2059289119 hasAuthorship W2059289119A5084027100 @default.
• W2059289119 hasAuthorship W2059289119A5087874511 @default.
• W2059289119 hasBestOaLocation W20592891191 @default.
• W2059289119 hasConcept C101762097 @default.
• W2059289119 hasConcept C104317684 @default.
• W2059289119 hasConcept C111936080 @default.
• W2059289119 hasConcept C121608353 @default.
• W2059289119 hasConcept C132376346 @default.

• next