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• W2059291012 startingPage "662" @default.
• W2059291012 abstract "A disturbing feature of hepatitis C virus (HCV) is its long-term persistence in roughly 85% of those infected. Escape mutants may play a major role in HCV persistence. Our previous studies have identified a human leukocyte antigen DRB1*15 (HLA-DRB1*15) restricted Th1 epitope in the HCV NS3 protein, NS3358-375, and escape variants of this epitope that may emerge under immune selection. Such variants attenuate or fail to stimulate T-cell proliferation. Here we provide data from peripheral blood mononuclear cells derived from four HLA-DRB1*15 patients chronically infected with HCV, and report that naturally occurring single amino acid substitutions in the Th1 epitope NS3358-375 fail to stimulate proliferation, which is accompanied by a shift in cytokine secretion patterns from one characteristic of a Th1 antiviral responses to a Th2 form. Further, in one patient, we demonstrate that HCV variant peptides can effectively inhibit host polyclonal peripheral T-cell proliferation. We speculate that this phenomenon may be a factor in chronic HCV infection." @default.
• W2059291012 created "2016-06-24" @default.
• W2059291012 creator A5033640233 @default.
• W2059291012 creator A5061483745 @default.
• W2059291012 creator A5083799579 @default.
• W2059291012 date "2003-07-01" @default.
• W2059291012 modified "2023-10-17" @default.
• W2059291012 title "Modulation of the peripheral T-Cell response by CD4 mutants of hepatitis C virus: transition from a Th1 to a Th2 response" @default.
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• W2059291012 doi "https://doi.org/10.1016/s0198-8859(03)00070-3" @default.
• W2059291012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12826368" @default.
• W2059291012 hasPublicationYear "2003" @default.
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