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- W2059291268 abstract "Breast cancer is a highly heterogeneous disease, an observation that underscores the importance of elucidating conserved molecular characteristics, such as gene and protein expression, across breast cancer cell types toward providing a greater understanding of context-specific features central to this disease. Motivated by the goal of defining central biological themes across breast cancer cell subtypes, we conducted a global proteomic analysis of three breast cancer cell lines, MCF7, SK-BR-3, and MDA-MB-231, and compared these to a model of nontransformed mammary cells (MCF10A). Our results demonstrate modulation of proteins localized to the extracellular matrix, plasma membrane, and nucleus, along with coordinate decreases in proteins that regulate cell spreading, a cellular event previously shown to be dysregulated in transformed cells. Protein interaction network analysis revealed the clustering of focal adhesion kinase (FAK), a fundamental regulator of cell spreading, with several proteins identified as mutually, differentially abundant across breast cancer cell lines that impact expression and activity of FAK, such as neprilysin and keratin 19. These analyses provide insights into conservation of protein expression across breast cancer cell subtypes, a subset of which warrants further investigation for their roles in the regulation of cell spreading and FAK in breast cancer." @default.
- W2059291268 created "2016-06-24" @default.
- W2059291268 creator A5006257784 @default.
- W2059291268 creator A5020102196 @default.
- W2059291268 creator A5041636520 @default.
- W2059291268 creator A5060699409 @default.
- W2059291268 creator A5080595928 @default.
- W2059291268 date "2010-08-03" @default.
- W2059291268 modified "2023-10-02" @default.
- W2059291268 title "Defining Central Themes in Breast Cancer Biology by Differential Proteomics: Conserved Regulation of Cell Spreading and Focal Adhesion Kinase" @default.
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- W2059291268 doi "https://doi.org/10.1021/pr100580e" @default.
- W2059291268 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20681588" @default.