FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059303288> ?p ?o ?g. }

• W2059303288 endingPage "673" @default.
• W2059303288 startingPage "668" @default.
• W2059303288 abstract "To investigate the effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) in the root canal treatment of apical periodontitis, we studied the healing process of experimentally induced periapical lesions in rats by using immunohistochemical methods. With a topical application of a combination of ofloxacin and FN-439 following experimentally induced periapical lesions, both neutrophils and macrophages became significantly decreased in number, while active cementogenesis and extensive bone formation were seen in the periapical region. However, the use of ofloxacin alone also demonstrated a beneficial effect on periapical inflammation and healing. Therefore, it is suggested that ofloxacin is powerful against bacterial infection whether FN-439 is added. The only observed effect of a combination of ofloxacin and FN-439 is that it may more effectively inhibit osteoclastic bone resorption and activate the remodeling of the apical periodontal tissue if this combined medicament is used in a stage of active bone destruction characterized by high production of tissue collagenase. To investigate the effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) in the root canal treatment of apical periodontitis, we studied the healing process of experimentally induced periapical lesions in rats by using immunohistochemical methods. With a topical application of a combination of ofloxacin and FN-439 following experimentally induced periapical lesions, both neutrophils and macrophages became significantly decreased in number, while active cementogenesis and extensive bone formation were seen in the periapical region. However, the use of ofloxacin alone also demonstrated a beneficial effect on periapical inflammation and healing. Therefore, it is suggested that ofloxacin is powerful against bacterial infection whether FN-439 is added. The only observed effect of a combination of ofloxacin and FN-439 is that it may more effectively inhibit osteoclastic bone resorption and activate the remodeling of the apical periodontal tissue if this combined medicament is used in a stage of active bone destruction characterized by high production of tissue collagenase." @default.
• W2059303288 created "2016-06-24" @default.
• W2059303288 creator A5007142203 @default.
• W2059303288 creator A5011485358 @default.
• W2059303288 creator A5036970355 @default.
• W2059303288 creator A5055931835 @default.
• W2059303288 creator A5072309313 @default.
• W2059303288 creator A5087076791 @default.
• W2059303288 date "1996-12-01" @default.
• W2059303288 modified "2023-09-25" @default.
• W2059303288 title "Effects of a combination of an antibacterial agent (ofloxacin) and a collagenase inhibitor (FN-439) on the healing of rat periapical lesions" @default.
• W2059303288 cites W1966138471 @default.
• W2059303288 cites W1994294759 @default.
• W2059303288 cites W2003755731 @default.
• W2059303288 cites W2004534384 @default.
• W2059303288 cites W2005055607 @default.
• W2059303288 cites W2008376989 @default.
• W2059303288 cites W2012206727 @default.
• W2059303288 cites W2012911819 @default.
• W2059303288 cites W2029178838 @default.
• W2059303288 cites W2034152249 @default.
• W2059303288 cites W2041306345 @default.
• W2059303288 cites W2056818301 @default.
• W2059303288 cites W2068406471 @default.
• W2059303288 cites W2069749800 @default.
• W2059303288 cites W2094221768 @default.
• W2059303288 cites W2101408941 @default.
• W2059303288 cites W2158228532 @default.
• W2059303288 cites W2163041426 @default.
• W2059303288 doi "https://doi.org/10.1016/s0099-2399(96)80061-6" @default.
• W2059303288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9220752" @default.
• W2059303288 hasPublicationYear "1996" @default.
• W2059303288 type Work @default.
• W2059303288 sameAs 2059303288 @default.
• W2059303288 citedByCount "9" @default.
• W2059303288 countsByYear W20593032882012 @default.
• W2059303288 countsByYear W20593032882014 @default.
• W2059303288 countsByYear W20593032882020 @default.
• W2059303288 crossrefType "journal-article" @default.
• W2059303288 hasAuthorship W2059303288A5007142203 @default.
• W2059303288 hasAuthorship W2059303288A5011485358 @default.
• W2059303288 hasAuthorship W2059303288A5036970355 @default.
• W2059303288 hasAuthorship W2059303288A5055931835 @default.
• W2059303288 hasAuthorship W2059303288A5072309313 @default.
• W2059303288 hasAuthorship W2059303288A5087076791 @default.
• W2059303288 hasConcept C142724271 @default.
• W2059303288 hasConcept C146562846 @default.
• W2059303288 hasConcept C181199279 @default.
• W2059303288 hasConcept C185592680 @default.
• W2059303288 hasConcept C199343813 @default.
• W2059303288 hasConcept C2778049240 @default.
• W2059303288 hasConcept C2778394429 @default.
• W2059303288 hasConcept C2778512257 @default.
• W2059303288 hasConcept C2779747767 @default.
• W2059303288 hasConcept C2780385504 @default.
• W2059303288 hasConcept C501593827 @default.
• W2059303288 hasConcept C55493867 @default.
• W2059303288 hasConcept C71924100 @default.
• W2059303288 hasConcept C98274493 @default.
• W2059303288 hasConceptScore W2059303288C142724271 @default.
• W2059303288 hasConceptScore W2059303288C146562846 @default.
• W2059303288 hasConceptScore W2059303288C181199279 @default.
• W2059303288 hasConceptScore W2059303288C185592680 @default.
• W2059303288 hasConceptScore W2059303288C199343813 @default.
• W2059303288 hasConceptScore W2059303288C2778049240 @default.
• W2059303288 hasConceptScore W2059303288C2778394429 @default.
• W2059303288 hasConceptScore W2059303288C2778512257 @default.
• W2059303288 hasConceptScore W2059303288C2779747767 @default.
• W2059303288 hasConceptScore W2059303288C2780385504 @default.
• W2059303288 hasConceptScore W2059303288C501593827 @default.
• W2059303288 hasConceptScore W2059303288C55493867 @default.
• W2059303288 hasConceptScore W2059303288C71924100 @default.
• W2059303288 hasConceptScore W2059303288C98274493 @default.
• W2059303288 hasIssue "12" @default.
• W2059303288 hasLocation W20593032881 @default.
• W2059303288 hasLocation W20593032882 @default.
• W2059303288 hasOpenAccess W2059303288 @default.
• W2059303288 hasPrimaryLocation W20593032881 @default.
• W2059303288 hasRelatedWork W149516013 @default.
• W2059303288 hasRelatedWork W2120014929 @default.
• W2059303288 hasRelatedWork W2385609028 @default.
• W2059303288 hasRelatedWork W2391400118 @default.
• W2059303288 hasRelatedWork W2968560129 @default.
• W2059303288 hasRelatedWork W2990199982 @default.
• W2059303288 hasRelatedWork W3087247436 @default.
• W2059303288 hasRelatedWork W4380589127 @default.
• W2059303288 hasRelatedWork W66850839 @default.
• W2059303288 hasRelatedWork W2403039959 @default.
• W2059303288 hasVolume "22" @default.
• W2059303288 isParatext "false" @default.
• W2059303288 isRetracted "false" @default.
• W2059303288 magId "2059303288" @default.
• W2059303288 workType "article" @default.