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• W2059315025 abstract "The C-cyclopropylalkylamide scaffold was previously identified as a new structural framework for antiestrogens. A second generation library provided three compounds that bind estrogen receptor (ER)α. Further screening of this library identified an ERβ hit and inspired another round of SAR. A new focused library was tested for binding to the ERs, and for effects on the growth of breast cancer cell lines and protein levels of common cell cycle regulators." @default.
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• W2059315025 date "2009-05-01" @default.
• W2059315025 modified "2023-10-11" @default.
• W2059315025 title "Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor β" @default.
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• W2059315025 doi "https://doi.org/10.1016/j.bmcl.2009.03.075" @default.
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