FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059331288> ?p ?o ?g. }

• W2059331288 abstract "In August 2002, the antifungal prophylaxis algorithm for neutropenic hematology/oncology (NHO) patients at the Medical Center was changed from conventional amphotericin (AMB) to an azole (AZ) based regimen (fluconazole [FLU] in low-risk and voriconazole [VOR] in high-risk patients). The aim of our study was to compare outcomes associated with the two regimens, including breakthrough fungal infection, adverse drug events, and costs. Adult, non-febrile, NHO patients who received prophylactic AMB from 8/01/01-7/30/02 or AZ from 8/01/02-7/30/03 were retrospectively evaluated. A total of 370 patients (AMB: n = 181; AZ: n = 216) associated with 580 hospitalizations (AMB: n = 259; AZ: n = 321) were included. The incidence of probable/definite breakthrough Aspergillus infections was similar among regimens (AMB: 1.9% vs AZ: 0.6%; p=0.19). A greater incidence of mild/moderate (24.7% vs. 5.3%; p < 0.0001) and severe renal dysfunction (13.5% vs. 4.4%; p < 0.0012) was observed with AMB. In contrast, patients treated with VOR were found to have an increased rate of severe hepatic toxicity (32.5%) compared with patients treated with either AMB (22.6%) or FLU (21.4%) (p = 0.05). While the AZ period was associated with a >$9,000 increase in mean total costs/hospitalization, the mean acquisition cost associated with AZ was only $947/hospitalization more than AMB. While an AZ-based regimen is associated with increased cost, the reduced rate of nephrotoxicity and availability of oral dosage forms, suggests that azoles be used preferentially over AMB. However, an increased rate of severe hepatic toxicity may be associated with VOR." @default.
• W2059331288 created "2016-06-24" @default.
• W2059331288 creator A5010756643 @default.
• W2059331288 creator A5048678762 @default.
• W2059331288 creator A5068053894 @default.
• W2059331288 creator A5077169512 @default.
• W2059331288 creator A5079269320 @default.
• W2059331288 creator A5079639357 @default.
• W2059331288 date "2007-07-02" @default.
• W2059331288 modified "2023-10-11" @default.
• W2059331288 title "Antifungal prophylaxis in chemotherapy-associated neutropenia: a retrospective, observational study" @default.
• W2059331288 cites W2003661565 @default.
• W2059331288 cites W2029714817 @default.
• W2059331288 cites W2060737754 @default.
• W2059331288 cites W2078654597 @default.
• W2059331288 cites W2082695689 @default.
• W2059331288 cites W2133328722 @default.
• W2059331288 cites W2166858780 @default.
• W2059331288 cites W2326799365 @default.
• W2059331288 doi "https://doi.org/10.1186/1471-2334-7-70" @default.
• W2059331288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1925090" @default.
• W2059331288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17605773" @default.
• W2059331288 hasPublicationYear "2007" @default.
• W2059331288 type Work @default.
• W2059331288 sameAs 2059331288 @default.
• W2059331288 citedByCount "16" @default.
• W2059331288 countsByYear W20593312882013 @default.
• W2059331288 countsByYear W20593312882014 @default.
• W2059331288 countsByYear W20593312882017 @default.
• W2059331288 countsByYear W20593312882019 @default.
• W2059331288 crossrefType "journal-article" @default.
• W2059331288 hasAuthorship W2059331288A5010756643 @default.
• W2059331288 hasAuthorship W2059331288A5048678762 @default.
• W2059331288 hasAuthorship W2059331288A5068053894 @default.
• W2059331288 hasAuthorship W2059331288A5077169512 @default.
• W2059331288 hasAuthorship W2059331288A5079269320 @default.
• W2059331288 hasAuthorship W2059331288A5079639357 @default.
• W2059331288 hasBestOaLocation W20593312881 @default.
• W2059331288 hasConcept C120665830 @default.
• W2059331288 hasConcept C121332964 @default.
• W2059331288 hasConcept C126189478 @default.
• W2059331288 hasConcept C126322002 @default.
• W2059331288 hasConcept C141071460 @default.
• W2059331288 hasConcept C16005928 @default.
• W2059331288 hasConcept C167135981 @default.
• W2059331288 hasConcept C197934379 @default.
• W2059331288 hasConcept C203014093 @default.
• W2059331288 hasConcept C2776391196 @default.
• W2059331288 hasConcept C2776694085 @default.
• W2059331288 hasConcept C2777063308 @default.
• W2059331288 hasConcept C2778850193 @default.
• W2059331288 hasConcept C2779548794 @default.
• W2059331288 hasConcept C2780402444 @default.
• W2059331288 hasConcept C2780651595 @default.
• W2059331288 hasConcept C2780690907 @default.
• W2059331288 hasConcept C2781413609 @default.
• W2059331288 hasConcept C2909039274 @default.
• W2059331288 hasConcept C29730261 @default.
• W2059331288 hasConcept C61511704 @default.
• W2059331288 hasConcept C71924100 @default.
• W2059331288 hasConcept C90924648 @default.
• W2059331288 hasConceptScore W2059331288C120665830 @default.
• W2059331288 hasConceptScore W2059331288C121332964 @default.
• W2059331288 hasConceptScore W2059331288C126189478 @default.
• W2059331288 hasConceptScore W2059331288C126322002 @default.
• W2059331288 hasConceptScore W2059331288C141071460 @default.
• W2059331288 hasConceptScore W2059331288C16005928 @default.
• W2059331288 hasConceptScore W2059331288C167135981 @default.
• W2059331288 hasConceptScore W2059331288C197934379 @default.
• W2059331288 hasConceptScore W2059331288C203014093 @default.
• W2059331288 hasConceptScore W2059331288C2776391196 @default.
• W2059331288 hasConceptScore W2059331288C2776694085 @default.
• W2059331288 hasConceptScore W2059331288C2777063308 @default.
• W2059331288 hasConceptScore W2059331288C2778850193 @default.
• W2059331288 hasConceptScore W2059331288C2779548794 @default.
• W2059331288 hasConceptScore W2059331288C2780402444 @default.
• W2059331288 hasConceptScore W2059331288C2780651595 @default.
• W2059331288 hasConceptScore W2059331288C2780690907 @default.
• W2059331288 hasConceptScore W2059331288C2781413609 @default.
• W2059331288 hasConceptScore W2059331288C2909039274 @default.
• W2059331288 hasConceptScore W2059331288C29730261 @default.
• W2059331288 hasConceptScore W2059331288C61511704 @default.
• W2059331288 hasConceptScore W2059331288C71924100 @default.
• W2059331288 hasConceptScore W2059331288C90924648 @default.
• W2059331288 hasIssue "1" @default.
• W2059331288 hasLocation W20593312881 @default.
• W2059331288 hasLocation W20593312882 @default.
• W2059331288 hasLocation W20593312883 @default.
• W2059331288 hasLocation W20593312884 @default.
• W2059331288 hasOpenAccess W2059331288 @default.
• W2059331288 hasPrimaryLocation W20593312881 @default.
• W2059331288 hasRelatedWork W2002259587 @default.
• W2059331288 hasRelatedWork W2104241036 @default.
• W2059331288 hasRelatedWork W2106365294 @default.
• W2059331288 hasRelatedWork W2108101200 @default.
• W2059331288 hasRelatedWork W2134577373 @default.
• W2059331288 hasRelatedWork W2137227869 @default.
• W2059331288 hasRelatedWork W2161750300 @default.
• W2059331288 hasRelatedWork W2384526635 @default.
• W2059331288 hasRelatedWork W2401094395 @default.

• next