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- W2059338259 abstract "Abstract Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and characterization of oncogenes and tumor suppressor genes. One new advance in this field is the identification of PTPN11 as the first proto-oncogene that encodes a cytoplasmic tyrosine phosphatase with 2 Src-homology 2 (SH2) domains (Shp2). This tyrosine phosphatase was previously shown to play an essential role in normal hematopoiesis. More recently, somatic missense PTPN11 gain-of-function mutations have been detected in leukemias and rarely in solid tumors, and have been found to induce aberrant hyperactivation of the Ras-Erk pathway. This progress represents another milestone in the leukemia/cancer research field and provides a fresh view on the molecular mechanisms underlying cell transformation." @default.
- W2059338259 created "2016-06-24" @default.
- W2059338259 creator A5038011899 @default.
- W2059338259 creator A5068516644 @default.
- W2059338259 date "2006-10-19" @default.
- W2059338259 modified "2023-10-10" @default.
- W2059338259 title "PTPN11 is the first identified proto-oncogene that encodes a tyrosine phosphatase" @default.
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- W2059338259 doi "https://doi.org/10.1182/blood-2006-07-028829" @default.
- W2059338259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1785139" @default.
- W2059338259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17053061" @default.
- W2059338259 hasPublicationYear "2006" @default.
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