FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2059338577> ?p ?o ?g. }

• W2059338577 endingPage "66" @default.
• W2059338577 startingPage "65" @default.
• W2059338577 abstract "We and others have previously demonstrated that delayed administration of the prodrug ganciclovir (GCV) protects mice from lethal GVHD while maintaining GVL activity after BMT with allogeneic naive (uncultured) thymidine kinase (TK)-expressing transgenic T cells. However, the efficacy of GCV control of GVHD and its impact on GVL activity following BMT with ex vivo activated, TK transduced and selected (Td) donor T cells has not been thoroughly characterized because of the significantly reduced GVHD-inducing potential of cultured cells compared to naive T cells in both preclinical models and initial clinical trials. In these experiments, we used A20 tumor cells (B cell lymphoma of BALB/c origin) that were modified to stably express a click beetle red luciferase-EGFP fusion reporter gene (A20-CBRluc/egfp) and monitored disease progression in vivo using optical bioluminescence imaging (BLI). To induce leukemia, BALB/c recipients were lethally irradiated and reconstituted with C57BL/6 BM supplemented with or without A20-CBRluc/egfp leukemia cells. Mice receiving leukemia cells were then left untreated or injected with 4 × 106 ΔCD34-TK (chimeric fusion suicide gene) Td donor T cells the day of BMT. Ten of ten BALB/c mice transplanted with BM and A20-CBRluc/egfp cells exhibited tumor engraftment and growth, with 8 mice dying from leukemia before day 35. In contrast, we observed no significant tumor signal in the majority (92%) of untreated (No GCV) mice that received ΔCD34-TK Td T cells. However, these animals developed GVHD with high mortality (P = .003 compared to BM only control) and significant weight loss (P < .05 from day 10 onward compared to BM only control). Although mice treated with GCV from days 4–10 after BMT were protected from GVHD, 50% of these animals developed leukemia. In contrast, none of the mice developed leukemia if GCV treatment was delayed until day 10 after BMT. Importantly, this GVL effect was obtained in the absence of GVHD, as evidenced by the improved survival (88% survival at day 60 post-BMT) and weight gain of the day 10–16 GCV treated mice compared to the untreated (No GCV) control. These data suggest that donor T cell dependent GVL effects against A20 cells can be preserved while the severity of GVHD is reduced, further demonstrating the potential of the HSV-TK/GCV system to reduce acute GVHD without impairing GVL activity." @default.
• W2059338577 created "2016-06-24" @default.
• W2059338577 creator A5042245154 @default.
• W2059338577 creator A5048491248 @default.
• W2059338577 creator A5051752608 @default.
• W2059338577 creator A5060952145 @default.
• W2059338577 creator A5065066309 @default.
• W2059338577 creator A5085384735 @default.
• W2059338577 date "2006-02-01" @default.
• W2059338577 modified "2023-09-24" @default.
• W2059338577 title "Delayed GCV-mediated ablation of ΔCD34-tk transduced and selected murine T cells preserves GVL activity while mitigating GVHD" @default.
• W2059338577 doi "https://doi.org/10.1016/j.bbmt.2005.11.206" @default.
• W2059338577 hasPublicationYear "2006" @default.
• W2059338577 type Work @default.
• W2059338577 sameAs 2059338577 @default.
• W2059338577 citedByCount "0" @default.
• W2059338577 crossrefType "journal-article" @default.
• W2059338577 hasAuthorship W2059338577A5042245154 @default.
• W2059338577 hasAuthorship W2059338577A5048491248 @default.
• W2059338577 hasAuthorship W2059338577A5051752608 @default.
• W2059338577 hasAuthorship W2059338577A5060952145 @default.
• W2059338577 hasAuthorship W2059338577A5065066309 @default.
• W2059338577 hasAuthorship W2059338577A5085384735 @default.
• W2059338577 hasConcept C10205521 @default.
• W2059338577 hasConcept C104317684 @default.
• W2059338577 hasConcept C111335760 @default.
• W2059338577 hasConcept C111599444 @default.
• W2059338577 hasConcept C150903083 @default.
• W2059338577 hasConcept C153911025 @default.
• W2059338577 hasConcept C161997846 @default.
• W2059338577 hasConcept C203014093 @default.
• W2059338577 hasConcept C207001950 @default.
• W2059338577 hasConcept C2522874641 @default.
• W2059338577 hasConcept C2776147627 @default.
• W2059338577 hasConcept C2777965375 @default.
• W2059338577 hasConcept C2778461978 @default.
• W2059338577 hasConcept C2779820661 @default.
• W2059338577 hasConcept C2780007613 @default.
• W2059338577 hasConcept C2781196997 @default.
• W2059338577 hasConcept C28328180 @default.
• W2059338577 hasConcept C34981463 @default.
• W2059338577 hasConcept C502942594 @default.
• W2059338577 hasConcept C54009773 @default.
• W2059338577 hasConcept C54355233 @default.
• W2059338577 hasConcept C55493867 @default.
• W2059338577 hasConcept C71924100 @default.
• W2059338577 hasConcept C81885089 @default.
• W2059338577 hasConcept C86803240 @default.
• W2059338577 hasConcept C95444343 @default.
• W2059338577 hasConceptScore W2059338577C10205521 @default.
• W2059338577 hasConceptScore W2059338577C104317684 @default.
• W2059338577 hasConceptScore W2059338577C111335760 @default.
• W2059338577 hasConceptScore W2059338577C111599444 @default.
• W2059338577 hasConceptScore W2059338577C150903083 @default.
• W2059338577 hasConceptScore W2059338577C153911025 @default.
• W2059338577 hasConceptScore W2059338577C161997846 @default.
• W2059338577 hasConceptScore W2059338577C203014093 @default.
• W2059338577 hasConceptScore W2059338577C207001950 @default.
• W2059338577 hasConceptScore W2059338577C2522874641 @default.
• W2059338577 hasConceptScore W2059338577C2776147627 @default.
• W2059338577 hasConceptScore W2059338577C2777965375 @default.
• W2059338577 hasConceptScore W2059338577C2778461978 @default.
• W2059338577 hasConceptScore W2059338577C2779820661 @default.
• W2059338577 hasConceptScore W2059338577C2780007613 @default.
• W2059338577 hasConceptScore W2059338577C2781196997 @default.
• W2059338577 hasConceptScore W2059338577C28328180 @default.
• W2059338577 hasConceptScore W2059338577C34981463 @default.
• W2059338577 hasConceptScore W2059338577C502942594 @default.
• W2059338577 hasConceptScore W2059338577C54009773 @default.
• W2059338577 hasConceptScore W2059338577C54355233 @default.
• W2059338577 hasConceptScore W2059338577C55493867 @default.
• W2059338577 hasConceptScore W2059338577C71924100 @default.
• W2059338577 hasConceptScore W2059338577C81885089 @default.
• W2059338577 hasConceptScore W2059338577C86803240 @default.
• W2059338577 hasConceptScore W2059338577C95444343 @default.
• W2059338577 hasIssue "2" @default.
• W2059338577 hasLocation W20593385771 @default.
• W2059338577 hasOpenAccess W2059338577 @default.
• W2059338577 hasPrimaryLocation W20593385771 @default.
• W2059338577 hasRelatedWork W2019713216 @default.
• W2059338577 hasRelatedWork W2048536214 @default.
• W2059338577 hasRelatedWork W2088877272 @default.
• W2059338577 hasRelatedWork W2132815178 @default.
• W2059338577 hasRelatedWork W2231628148 @default.
• W2059338577 hasRelatedWork W2605837602 @default.
• W2059338577 hasRelatedWork W2790544026 @default.
• W2059338577 hasRelatedWork W2957788206 @default.
• W2059338577 hasRelatedWork W2981589400 @default.
• W2059338577 hasRelatedWork W3146686734 @default.
• W2059338577 hasVolume "12" @default.
• W2059338577 isParatext "false" @default.
• W2059338577 isRetracted "false" @default.
• W2059338577 magId "2059338577" @default.
• W2059338577 workType "article" @default.