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• W2059343860 abstract "The role of protein kinase C in controlling L‐arginine transport in alveolar macrophages was investigated. L‐[ 3 H]Arginine uptake in rabbit alveolar macrophages declined by 80 % after 20 h in culture. 4β‐Phorbol 12‐myristate 13‐acetate (PMA), but not 4α‐phorbol 12‐myristate 13‐acetate (α‐PMA), present during 20 h culture, enhanced L‐[ 3 H]arginine uptake more than 10‐fold. Staurosporine and chelerythrine opposed this effect. L‐[ 3 H]Arginine uptake was saturable and blockable by L‐lysine. After PMA treatment V max was increased more than 5‐fold and K m was reduced from 0.65 to 0.32 mM. Time course experiments showed that PMA increased L‐[ 3 H]arginine uptake almost maximally within 2 h. This short‐term effect was not affected by cycloheximide or actinomycin D. L‐[ 3 H]Arginine uptake and its stimulation by PMA was also observed in sodium‐free medium. L‐Leucine (0.1 mM) inhibited L‐[ 3 H]arginine uptake by 50 % in sodium‐containing medium, but not in sodium‐free medium. At 1 mM, L‐leucine caused significant inhibition in sodium‐free medium also. L‐Leucine showed similar effects on PMA‐treated cells. N‐ Ethylmaleimide (200 μ m , 10 min) reduced L‐[ 3 H]arginine uptake by 70 % in control cells, but had no effect on PMA‐treated (20 or 2 h) cells. In alveolar macrophages, multiple transport systems are involved in L‐arginine uptake, which is markedly stimulated by protein kinase C, probably by modulation of the activity of already expressed cationic amino acid transporters." @default.
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• W2059343860 date "1998-09-01" @default.
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• W2059343860 title "Activation of L-arginine transport by protein kinase C in rabbit, rat and mouse alveolar macrophages" @default.
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• W2059343860 doi "https://doi.org/10.1111/j.1469-7793.1998.813bg.x" @default.
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