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- W2059357162 abstract "Abstract The dissolution of an experimental formulation of film-coated slow release theophylline mini-tablets has been investigated using the USP paddle apparatus in test media at pH 1·2 (hydrochloric acid), pH 5·4 and 7·4 (phosphate buffers) at 37°C. Monitoring of in-vitro theophylline release over 12 h, under identical hydrodynamic conditions, showed that the dissolution rate at pH 1·2 is substantially greater (95% of total drug content released in < 10 h) than that in phosphate buffers. The maximum release after 12 h was approximately 20 and 30% of total drug content of the tablet at pH 5·4 and 7·4, respectively. However, in-vivo bioavailability after oral administration of tablets to rabbits corresponded to over 95% of total drug, compared with the same dose administered intravenously. The retarded drug release during in-vitro dissolution in phosphate buffer was attributed to a possible interaction of phosphate ions with theophylline molecules at the tablet core-coat interface. These findings indicate that both rate and extent of theophylline release from the slow release coated mini-tablets are highly sensitive to phosphate buffers. The data also emphasize the usefulness of an animal model for assessment of in-vivo drug release and subsequent absorption, during the development of modified release dosage forms." @default.
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- W2059357162 date "1989-06-01" @default.
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- W2059357162 title "Dissolution of Theophylline from Film-coated Slow Release Mini-tablets in Various Dissolution Media" @default.
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- W2059357162 doi "https://doi.org/10.1111/j.2042-7158.1989.tb06479.x" @default.
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