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• W2059360060 abstract "Inverse metabolic engineering attempts to identify or construct desired phenotypes of applied interest to endow them on appropriate host organisms. A particular desirable phenotype is the ATP homeostasis exhibited by animal cells with high and variable ATP turnover through temporal and spatial energy buffering. This buffering is achieved by phosphagen kinase systems that consist of a specific kinase and its cognate phosphagen, which functions as a large pool of ‘high-energy phosphates’ that are used to replenish ATP during periods of high energetic demand. This review discusses recent advances and potentials of inverse metabolic engineering of cell types that do not normally contain such systems—bacteria, yeast, plants, and liver—with creatine or arginine kinase systems. Examples are discussed that illustrate how microbial metabolism can be tailored for large-scale industrial processes with imperfect mixing and how the liver can be protected from metabolic insults or stimulated for better regeneration." @default.
• W2059360060 created "2016-06-24" @default.
• W2059360060 creator A5002057344 @default.
• W2059360060 creator A5014164691 @default.
• W2059360060 date "2004-07-01" @default.
• W2059360060 modified "2023-10-16" @default.
• W2059360060 title "Inverse metabolic engineering with phosphagen kinase systems improves the cellular energy state" @default.
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• W2059360060 doi "https://doi.org/10.1016/j.ymben.2003.11.004" @default.
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• W2059360060 hasPublicationYear "2004" @default.
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